1-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-CYCLOPROPANOL

Base Information

• Chemical Name: 1-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-CYCLOPROPANOL
• CAS No.: 441784-82-3
• Molecular Formula: C₂₀H₂₆O₂Si
• Molecular Weight: 326.511
• Mol file: 441784-82-3.mol

Synonyms:

Chemical Property of 1-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-CYCLOPROPANOL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 392.095oC at 760 mmHg
• PKA: 14.39±0.20(Predicted)
• Flash Point: 190.933oC
• PSA: 29.46000
• Density: 1.08g/cm3
• LogP: 3.08790
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-(((tert-Butyldiphenylsilyl)-oxy)methyl)cyclopropanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-CYCLOPROPANOL

There total 3 articles about 1-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-CYCLOPROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethylmagnesium bromide (925-90-6) + 2-((tert-butyl(diphenyl)silyl)oxy)acetic acid ethyl ester (441784-83-4) → 1-(((tert-butyldiphenylsilyl)oxy)methyl)cyclopropan-1-ol (441784-82-3)

Guidance literature:

ethylmagnesium bromide; 2-((tert-butyl(diphenyl)silyl)oxy)acetic acid ethyl ester; With titanium(IV) isopropylate; In tetrahydrofuran; at 20 ℃; for 12h;

With ammonium chloride; In tetrahydrofuran;

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 1-(((tert-butyldiphenylsilyl)oxy)methyl)cyclopropan-1-ol (441784-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 16 h / 20 °C / Cooling with ice

2: titanium(IV)isopropoxide / tetrahydrofuran / 4 h / -15 - 20 °C / Inert atmosphere

With 1H-imidazole; titanium(IV)isopropoxide; In tetrahydrofuran; dichloromethane;

Reference yield:

methyl 2-((tert-butyl(diphenyl)silyl)oxy)acetate (154698-92-7) → 1-(((tert-butyldiphenylsilyl)oxy)methyl)cyclopropan-1-ol (441784-82-3)

Guidance literature:

DOI:10.1039/c5cc02386f

upstream raw materials:

ethylmagnesium bromide

2-((tert-butyl(diphenyl)silyl)oxy)acetic acid ethyl ester

methyl 2-((tert-butyl(diphenyl)silyl)oxy)acetate

tert-butylchlorodiphenylsilane