2-[1-(Benzenesulfonyl)indol-4-yl]oxyethanamine

Base Information

Chemical Name:2-[1-(Benzenesulfonyl)indol-4-yl]oxyethanamine
CAS No.:444190-28-7
Molecular Formula:C16H16N2O3S
Molecular Weight:316.381
Hs Code.:
DSSTox Substance ID:DTXSID50437660
Wikidata:Q82253201
ChEMBL ID:CHEMBL361341

Synonyms:2-[1-(benzenesulfonyl)indol-4-yl]oxyethanamine;444190-28-7;CHEMBL361341;SCHEMBL4082851;DTXSID50437660;QCDGAAZKPYXOQQ-UHFFFAOYSA-N;2-{[1-(phenylsulfonyl)-1H-indole-4yl]oxy}ethylamine;2-{[1-(Phenylsulfonyl)-1H-indole-4-Y]oxy}ethylamine;2-{[1-(phenylsulfonyl)-1H-indole-4-yl]oxy}ethylamine

Suppliers and Price of 2-[1-(Benzenesulfonyl)indol-4-yl]oxyethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 2-[1-(Benzenesulfonyl)indol-4-yl]oxyethanamine

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:316.08816355
Heavy Atom Count:22
Complexity:457

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)S(=O)(=O)N2C=CC3=C2C=CC=C3OCCN

Technology Process of 2-[1-(Benzenesulfonyl)indol-4-yl]oxyethanamine

There total 8 articles about 2-[1-(Benzenesulfonyl)indol-4-yl]oxyethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2-(2-((1-(phenylsulfonyl)-1H-indol-4-yl)oxy)ethyl)isoindoline-1,3-dione

: 444190-28-7
2-((1-(phenylsulfonyl)-1H-indol-4-yl)oxy)ethan-1-amine

Guidance literature:: 2-(2-((1-(phenylsulfonyl)-1H-indol-4-yl)oxy)ethyl)isoindoline-1,3-dione; With methylamine; In water; at 50 ℃;

With sodium hydroxide; In water;
DOI:10.1016/j.ejmech.2021.113783

Reference yield:

: 79315-62-1
4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole

: 444190-28-7
2-((1-(phenylsulfonyl)-1H-indol-4-yl)oxy)ethan-1-amine

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 45 °C

2: potassium carbonate / ethanol / 48 h / 80 °C

3: 18-crown-6 ether / N,N-dimethyl-formamide / 24 h / 50 °C

4: methylamine / water / 50 °C

With 18-crown-6 ether; palladium 10% on activated carbon; hydrogen; potassium carbonate; methylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2021.113783

Reference yield:

: 95969-13-4
1-Benzenesulfonyl-4-hydroxy-1H-indole

: 444190-28-7
2-((1-(phenylsulfonyl)-1H-indol-4-yl)oxy)ethan-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / ethanol / 48 h / 80 °C

2: 18-crown-6 ether / N,N-dimethyl-formamide / 24 h / 50 °C

3: methylamine / water / 50 °C

With 18-crown-6 ether; potassium carbonate; methylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2021.113783