2-Propenoic acid, 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl ]phenyl]-1H-imidazol-5-yl]-, methyl ester, (2E)-

Base Information

Chemical Name:2-Propenoic acid, 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl ]phenyl]-1H-imidazol-5-yl]-, methyl ester, (2E)-
CAS No.:444622-25-7
Molecular Formula:C₁₉H₁₈F₆N₂O₃
Molecular Weight:436.354
Hs Code.:

2-Propenoic acid,
3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl
]phenyl]-1H-imidazol-5-yl]-, methyl ester, (2E)-

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Chemical Property of 2-Propenoic acid, 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl ]phenyl]-1H-imidazol-5-yl]-, methyl ester, (2E)-

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Technology Process of 2-Propenoic acid, 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl ]phenyl]-1H-imidazol-5-yl]-, methyl ester, (2E)-

There total 3 articles about 2-Propenoic acid, 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl ]phenyl]-1H-imidazol-5-yl]-, methyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876143-22-5
N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-isobutyramidine

: 444622-25-7
3-{2-isopropyl-3-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-3H-imidazol-4-yl}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. K₂CO₃ / CHCl₃

2: toluene

With potassium carbonate; In chloroform; toluene; 2: Wittig reaction;
DOI:10.1016/j.bmcl.2005.10.020

Reference yield:

: 722-92-9
2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 444622-25-7
3-{2-isopropyl-3-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-3H-imidazol-4-yl}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. K₂CO₃ / CHCl₃

2: toluene

With potassium carbonate; In chloroform; toluene; 3: Wittig reaction;
DOI:10.1016/j.bmcl.2005.10.020