Methanone, (2-iodo-5-nitrophenyl)[1-[[(2R)-1-methyl-2-piperidinyl]methyl]-1H-indol-3 -yl]-

Base Information

• Chemical Name: Methanone, (2-iodo-5-nitrophenyl)[1-[[(2R)-1-methyl-2-piperidinyl]methyl]-1H-indol-3 -yl]-
• CAS No.: 444912-51-0
• Molecular Formula: C₂₂H₂₂IN₃O₃
• Molecular Weight: 503.339

Synonyms:

Chemical Property of Methanone, (2-iodo-5-nitrophenyl)[1-[[(2R)-1-methyl-2-piperidinyl]methyl]-1H-indol-3 -yl]-

Chemical Property:

• PSA: 71.06000
• LogP: 5.33050

Purity/Quality:

99% ^*data from raw suppliers

(R)-AM1241 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: (R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts as an agonist at human CB2 receptors (EC50 = 118 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 315 and 341 nM, respectively). Similar to the racemate AM1241 , (R)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing effect of (R)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone ( | ISO60191).
• Uses: (R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor. Synthetic cannabinoid.Synthetic Cannabinoids

Technology Process of Methanone, (2-iodo-5-nitrophenyl)[1-[[(2R)-1-methyl-2-piperidinyl]methyl]-1H-indol-3 -yl]-

There total 3 articles about Methanone, (2-iodo-5-nitrophenyl)[1-[[(2R)-1-methyl-2-piperidinyl]methyl]-1H-indol-3 -yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

indole (120-72-9) → (2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone (444912-51-0,444912-48-5,444912-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: EtMgBr; ZnCl₂

2: NaH

With ethylmagnesium bromide; sodium hydride; zinc(II) chloride;

DOI:10.1038/sj.bjp.0706838

Reference yield:

2-iodo-5-nitrobenzoic acid chloride (860567-09-5) → (2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone (444912-51-0,444912-48-5,444912-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: EtMgBr; ZnCl₂

2: NaH

With ethylmagnesium bromide; sodium hydride; zinc(II) chloride;

DOI:10.1038/sj.bjp.0706838

Reference yield:

(1H-indol-3-yl)-(2-iodo-5-nitro-phenyl)-methanone + (1-methylpiperidin-2-yl)methyl methanesulfonate (907160-87-6) → (2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone (444912-51-0,444912-48-5,444912-53-2)

Guidance literature:

With sodium hydride;

DOI:10.1038/sj.bjp.0706838

upstream raw materials:

(1-methylpiperidin-2-yl)methyl methanesulfonate

indole

2-iodo-5-nitrobenzoic acid chloride

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