1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1,1-dimethylethyl ester, (2S,4R)-

Base Information

• Chemical Name: 1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1,1-dimethylethyl ester, (2S,4R)-
• CAS No.: 445305-87-3
• Molecular Formula: C34H39N3O7
• Molecular Weight: 601.7
• Mol file: 445305-87-3.mol

Synonyms:

Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1,1-dimethylethyl ester, (2S,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1,1-dimethylethyl ester, (2S,4R)-

There total 12 articles about 1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1,1-dimethylethyl ester, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride (681807-60-3,259214-54-5,259214-56-7) + (2S,4R)-1-(tert-butoxycarbonyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxylic acid (259214-37-4) → (2S,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (445305-87-3) + (2S,4R)-2-((1S,2R)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (445305-88-4)

Guidance literature:

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Product distribution / selectivity;

Reference yield: 44.0%

(trans)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride (259214-54-5,259214-56-7) + (2S,4R)-1-(tert-butoxycarbonyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxylic acid (259214-37-4) → (2S,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (445305-87-3) + (2S,4R)-2-((1S,2R)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (445305-88-4)

Guidance literature:

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Product distribution / selectivity;

Reference yield:

(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate (746657-36-3,213316-32-6,259221-73-3) + (2S,4R)-1-(tert-butoxycarbonyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxylic acid (259214-37-4) → (2S,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (445305-87-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; at 20 ℃;

DOI:10.1021/jo049288r

upstream raw materials:

(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate

(2S,4R)-1-(tert-butoxycarbonyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxylic acid

7-methoxy-2-phenylquinolin-4-ol

m-Anisidine

Downstream raw materials:

1-{[4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

1-[[[(2S,4R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[(7-methoxy-2-phenyl-4-quinolinyl)oxy]-2-pyrrolidinyl]carbonyl]amino]-2-ethenyl-(1R,2S)-cyclopropanecarboxylic acid