Cyclobutanesulfonamide

Base Information

• Chemical Name: Cyclobutanesulfonamide
• CAS No.: 445305-91-9
• Molecular Formula: C4H9NO2S
• Molecular Weight: 135.187
• European Community (EC) Number: 841-117-4
• DSSTox Substance ID: DTXSID20570371
• Wikidata: Q82457782
• Mol file: 445305-91-9.mol

Synonyms:CYCLOBUTANESULFONAMIDE;445305-91-9;Cyclobutanesulfonamide (9CI);MFCD16658702;Cyclobutanesulfonamide(9ci);cyclobutanesulfonic acid amide;SCHEMBL636980;DTXSID20570371;HYMXQESPSIAYCN-UHFFFAOYSA-N;AKOS017515064;SY163437;CS-0139177;C77469;EN300-180987;Z1255426083

Chemical Property of Cyclobutanesulfonamide

Chemical Property:

• PSA: 68.54000
• LogP: 1.60850
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 135.03539970
• Heavy Atom Count: 8
• Complexity: 163

Purity/Quality:

99% ^*data from raw suppliers

cyclobutanesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(C1)S(=O)(=O)N

Technology Process of Cyclobutanesulfonamide

There total 3 articles about Cyclobutanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

Bromocyclobutane (4399-47-7) → cyclobutyl sulfonamide (445305-91-9)

Guidance literature:

Bromocyclobutane; With tert.-butyl lithium; In diethyl ether; pentane; at -78 - -35 ℃; for 1.5h;

With sulfuryl dichloride; In diethyl ether; hexane; pentane; at -40 - 0 ℃; for 1h;

With ammonia; In tetrahydrofuran;

Reference yield: 38.0%

cyclobutanesulfonyl chloride (338453-16-0) → cyclobutyl sulfonamide (445305-91-9)

Guidance literature:

With ammonia; In tetrahydrofuran;

Reference yield: 25.0%

2-(cyclobutylsulfonyl)pyrimidine → cyclobutyl sulfonamide (445305-91-9)

Guidance literature:

2-(cyclobutylsulfonyl)pyrimidine; With sodium methylate; In methanol; at 0 ℃; for 0.5h;

With sodium acetate; hydroxylamine-O-sulfonic acid; In methanol; water; at 20 ℃; for 16h;

upstream raw materials:

cyclobutanesulfonyl chloride

Bromocyclobutane

Downstream raw materials:

5-[13-cyclohexyl-3-methoxy-10-[[[(cyclobutyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

Refernces

• 1、 -. "CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS". Page/Page column 109-110. . Retrieved 2009/06/27.
• 2、 -. "Hepatitis C Virus Inhibitors". . . Retrieved 2009/12/24.