3-[5-(Benzyloxy)-1H-indol-1-yl]propanoic acid

Base Information

• Chemical Name: 3-[5-(Benzyloxy)-1H-indol-1-yl]propanoic acid
• CAS No.: 445492-18-2
• Molecular Formula: C18H17NO3
• Molecular Weight: 295.338
• Hs Code.: 2933990090
• Mol file: 445492-18-2.mol

Synonyms:5-(aminomethyl)-4-(carboxymethyl)-pyrrole-3-propionic acid;2-aminomethylpyrrol-3-acetic acid 4-propionic acid;3-(5-Benzyloxy-indol-1-yl)-propionic acid;3-(5-aminomethyl-4-carboxymethyl-pyrrol-3-yl)-propionic acid;5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrole-3-propionic acid;1H-Pyrrole-3-propanoic acid,5-(aminomethyl)-4-(carboxymethyl);3-(5-Aminomethyl-4-carboxymethyl-pyrrol-3-yl)-propionsaeure;PBG;3-(5-aminomethyl-4-carboxymethyl-1H-pyrrol-3-yl)propionic acid;3-(5-benzyloxyindolyl)propanic acid;5-[Aminomethyl]-4-[carboxymethyl]-1H-pyrrole-3-propanoic acid;porphobilinogen;

Chemical Property of 3-[5-(Benzyloxy)-1H-indol-1-yl]propanoic acid

Chemical Property:

• Boiling Point: 523.5±35.0 °C(Predicted)
• PKA: 4.55±0.10(Predicted)
• PSA: 51.46000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 3.69500

Purity/Quality:

98%min ^*data from raw suppliers

3-[5-(Benzyloxy)-1H-indol-1-yl]propanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[5-(Benzyloxy)-1H-indol-1-yl]propanoic acid

There total 3 articles about 3-[5-(Benzyloxy)-1H-indol-1-yl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

Ethyl 3-bromopropionate (539-74-2) + 5-benzyloxy-1H-indole (1215-59-4) → 3-(5-Benzyloxy-indol-1-yl)-propionic acid (445492-18-2)

Guidance literature:

With potassium hydroxide; acetic acid; In dimethyl sulfoxide;

Reference yield:

5-benzyloxy-1H-indole (1215-59-4) + Ethyl 2-bromopropionate (535-11-5,41978-69-2) → 3-(5-Benzyloxy-indol-1-yl)-propionic acid (445492-18-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

→ 3-(5-Benzyloxy-indol-1-yl)-propionic acid (445492-18-2)

Guidance literature:

upstream raw materials:

Ethyl 3-bromopropionate

5-benzyloxy-1H-indole

Ethyl 2-bromopropionate

Downstream raw materials:

3-(5-Benzyloxy-indol-1-yl)-propionic acid methyl ester

Refernces

• 1、 -. "Antidiabetic agents". . . Retrieved 2008/06/13.