2-(2-Bromopyridin-4-yl)-1-(pyridin-2-yl)ethanone

Base Information

Chemical Name:2-(2-Bromopyridin-4-yl)-1-(pyridin-2-yl)ethanone
CAS No.:446852-65-9
Molecular Formula:C12H9BrN2O
Molecular Weight:277.12
Hs Code.:2933399990
DSSTox Substance ID:DTXSID30467884
Mol file:446852-65-9.mol

Synonyms:446852-65-9;2-(2-Bromopyridin-4-yl)-1-(pyridin-2-yl)ethanone;2-(2-BROMO-PYRIDIN-4-YL)-1-PYRIDIN-2-YL-ETHANONE;2-(2-bromopyridin-4-yl)-1-pyridin-2-ylethanone;2-(2-bromopyridin-4-yl)-1-(pyridin-2-yl)ethan-1-one;2-[2-Bromo-pyridin-4-yl]-1-pyridin-2-yl-ethanone;2-(2-bromopyridin-4-yl)-1-(pyridine-2-yl)ethanone;SCHEMBL5789056;DTXSID30467884;RKVGSLYSLROWJI-UHFFFAOYSA-N;WSA85265;MFCD09031951;AKOS015965658;CS-13246;CS-0000073;Y11286;1-pyridin-2-yl-2-[2-bromo-pyridin-4-y]-ethanone;1-Pyridin-2-yl-2-[2-bromo-pyridin-4-yl]-ethanone

Suppliers and Price of 2-(2-Bromopyridin-4-yl)-1-(pyridin-2-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-(2-Bromopyridin-4-yl)-1-(pyridin-2-yl)ethanone 95+%
250mg
$ 192.00

Crysdot
2-(2-Bromopyridin-4-yl)-1-(pyridin-2-yl)ethanone 95+%
1g
$ 480.00

Chemenu
2-(2-bromopyridin-4-yl)-1-(pyridin-2-yl)ethan-1-one 95%
1g
$ 449.00

American Custom Chemicals Corporation
2-(2-BROMO-PYRIDIN-4-YL)-1-PYRIDIN-2-YL-ETHANONE 95.00%
5MG
$ 502.32

Alichem
2-(2-Bromopyridin-4-yl)-1-(pyridin-2-yl)ethanone
1g
$ 422.92

Alichem
2-(2-Bromopyridin-4-yl)-1-(pyridin-2-yl)ethanone
250mg
$ 211.20

Total 13 raw suppliers

Chemical Property of 2-(2-Bromopyridin-4-yl)-1-(pyridin-2-yl)ethanone

Chemical Property:

Storage Temp.:2-8°C
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:275.98983
Heavy Atom Count:16
Complexity:247

Purity/Quality:

99.0% ^*data from raw suppliers

2-(2-Bromopyridin-4-yl)-1-(pyridin-2-yl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=NC(=C1)C(=O)CC2=CC(=NC=C2)Br

Technology Process of 2-(2-Bromopyridin-4-yl)-1-(pyridin-2-yl)ethanone

There total 1 articles about 2-(2-Bromopyridin-4-yl)-1-(pyridin-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 4926-28-7
2-Bromo-4-picoline

: 2524-52-9,1228273-66-2
ethyl-2-picolinate

: 446852-65-9
2-(2-bromopyridin-4-yl)-1-(pyridin-2-yl)ethan-1-one

Guidance literature:: 2-Bromo-4-picoline; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -50 ℃; for 0.5h; Inert atmosphere;

ethyl-2-picolinate; In tetrahydrofuran; toluene; at -50 - 45 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.12.120

Reference yield:

: 446852-65-9
2-(2-bromopyridin-4-yl)-1-(pyridin-2-yl)ethan-1-one

: 446880-83-7
2-bromo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / dimethylformamide / 1.3 h / 20 °C

2: 45.8 g / hydrazine monohydrate / dimethylformamide / 2 h / 50 °C

3: 85.3 percent / potassium carbonate / acetone / 24 h / Heating

With potassium carbonate; hydrazine hydrate; acetic acid; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm0509905

Reference yield:

: 446852-65-9
2-(2-bromopyridin-4-yl)-1-(pyridin-2-yl)ethan-1-one

: 4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)-2-(4-pyrrolidin-1-ylmethyl-phenyl)-pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / dimethylformamide / 1.3 h / 20 °C

2: 45.8 g / hydrazine monohydrate / dimethylformamide / 2 h / 50 °C

3: 85.3 percent / potassium carbonate / acetone / 24 h / Heating

4: 85 percent / aq. Na₂CO₃; tetrakis(triphenylphosphine)palladium / ethanol; toluene / 2 h / Heating

5: AcOH; NaHB(OAc)3 / CH₂Cl₂ / 20 °C

6: HCl / methanol / 2.5 h / Heating

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tris(acetoxy)borohydride; sodium carbonate; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; 4: Suzuki coupling;
DOI:10.1021/jm0509905