Technology Process of Carbamic acid,
[(1R)-2-[(3-hexylphenyl)amino]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-,
1,1-dimethylethyl ester
There total 4 articles about Carbamic acid,
[(1R)-2-[(3-hexylphenyl)amino]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-,
1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-Boc-D-serine(Bzl)-OH;
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
for 0.0833333h;
3-hexylphenylamine;
In
dichloromethane;
for 4h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen / palladium on activated charcoal / ethanol / 12 h
2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h
2.2: 4 h
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis(dibenzylideneacetone)-palladium(0) / tetrahydrofuran / 12 h / 20 °C
2.1: hydrogen / palladium on activated charcoal / ethanol / 12 h
3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h
3.2: 4 h
With
copper(l) iodide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
palladium on activated charcoal; bis(dibenzylideneacetone)-palladium(0);
In
tetrahydrofuran; ethanol; dichloromethane;
