Hydrazinecarboxylic acid, 2-(2-ethoxy-2-oxoethyl)-, phenylmethyl ester

Base Information

• Chemical Name: Hydrazinecarboxylic acid, 2-(2-ethoxy-2-oxoethyl)-, phenylmethyl ester
• CAS No.: 4503-58-6
• Molecular Formula: C12H16N2O4
• Molecular Weight: 252.27
• Mol file: 4503-58-6.mol

Synonyms:(N'-Benzyloxycarbonyl-hydrazino)-acetic acid ethyl ester;Nβ-Benzyloxycarbonyl-hydrazinoacetic acid ethyl ester;

Chemical Property of Hydrazinecarboxylic acid, 2-(2-ethoxy-2-oxoethyl)-, phenylmethyl ester

Chemical Property:

• Melting Point: 95 - 97 °C
• PSA: 76.66000
• LogP: 1.76230

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hydrazinecarboxylic acid, 2-(2-ethoxy-2-oxoethyl)-, phenylmethyl ester

There total 6 articles about Hydrazinecarboxylic acid, 2-(2-ethoxy-2-oxoethyl)-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + 2-hydrazinyl acetic acid ethyl ester hydrochloride (6945-92-2) → benzyl 2-(2-ethoxy-2-ethoxyethyl)-1-hydrazinecarboxylate (4503-58-6)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; 1) 0 deg C, 4 h, 2) r.t., 1 h;

DOI:10.1016/S0223-5234(98)80043-3

Reference yield: 70.0%

2-hydrazinyl acetic acid ethyl ester hydrochloride (6945-92-2) + N-(benzyloxycarbonyl)succinimide (75315-63-8) → benzyl 2-(2-ethoxy-2-ethoxyethyl)-1-hydrazinecarboxylate (4503-58-6)

Guidance literature:

With 4-methyl-morpholine; at 0 - 20 ℃;

DOI:10.1021/jm000094n

Reference yield:

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + 2-hydrazinyl acetic acid ethyl ester hydrochloride (6945-92-2) → benzyl 2-(2-ethoxy-2-ethoxyethyl)-1-hydrazinecarboxylate (4503-58-6) + Nα-Benzyloxycarbonyl-hydrazinoessigsaeure-ethylester (4467-44-1)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/0040-4039(91)85080-O

upstream raw materials:

(N-(tert-butoxycarbonyl)hydrazino)acetic acid ethyl ester

benzyl chloroformate

N-(Benzyloxycarbonyloxy)succinimide

2-hydrazinyl acetic acid ethyl ester hydrochloride

Downstream raw materials:

benzyl 2-(2-amino-2-oxoethyl)hydrazinecarboxylate

benzyl 2-ethoxycarbonylacetyl-2-(ethoxycarbonylmethyl)hydrazine-1-carboxylate

Piv-Proψα(N^βHZ)>Gly-NHiPr

benzyl 2-ethoxycarbonyldiazoacetyl-2-(ethoxycarbonylmethyl)hydrazine-1-carboxylate