N'-hydroxy-3-iodobenzenecarboximidamide

Base Information

• Chemical Name: N'-hydroxy-3-iodobenzenecarboximidamide
• CAS No.: 453565-59-8
• Molecular Formula: C7H7IN2O
• Molecular Weight: 262.05
• Mol file: 453565-59-8.mol

Synonyms:

Chemical Property of N'-hydroxy-3-iodobenzenecarboximidamide

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 261.96031
• Heavy Atom Count: 11
• Complexity: 161

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)I)C(=NO)N
• Isomeric SMILES: C1=CC(=CC(=C1)I)/C(=N\O)/N

Technology Process of N'-hydroxy-3-iodobenzenecarboximidamide

There total 3 articles about N'-hydroxy-3-iodobenzenecarboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-iodobenzonitrile (69113-59-3) → N'-hydroxy-3-iodobenzimidamide (453565-59-8)

Guidance literature:

With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; at 90 ℃; for 2h;

Reference yield: 95.0%

3-iodobenzonitrile (69113-59-3) → N-hydroxy-3-iodo-benzamidine (453565-59-8)

Guidance literature:

With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; at 80 ℃;

DOI:10.1016/j.tetlet.2006.12.050

Reference yield: 95.0%

3-iodobenzonitrile (69113-59-3) → N-hydroxy-3-iodobenzamidine (453565-59-8)

Guidance literature:

With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; at 80 ℃;

DOI:10.1016/j.bmcl.2008.11.040

upstream raw materials:

3-iodobenzonitrile

Downstream raw materials:

3-(3-iodo-phenyl)-4H-[1,2,4]oxadiazol-5-one

3-(3-cyanophenyl)-5-(pyridin-2-yl)-1,2,4-oxadiazole

3-(3-iodophenyl)-5-(pyridin-2-yl)-1,2,4-oxadiazole

1-iodo-3-(5-methyl-[1,2,4]oxadiazol-3-yl)benzene

Refernces

• 1、 -. "PYRIMIDODIAZEPINONE DERIVATIVE". Page/Page column 77. . Retrieved 2010/04/24.
• 2、 Charton, Julie,Cousaert, Nicolas,Bochu, Christophe,Willand, Nicolas,Déprez, Beno?t,Déprez-Poulain, Rébecca. "A versatile solid-phase synthesis of 3-aryl-1,2,4-oxadiazolones and analogues". . p. 1479 - 1483. Retrieved 2008/02/02.