N''-[4-(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl]-N,N-dimethylsulfamide

Base Information

Chemical Name:N''-[4-(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl]-N,N-dimethylsulfamide
CAS No.:454219-13-7
Molecular Formula:C₁₈H₂₄ClN₃O₃S
Molecular Weight:397.926
Hs Code.:
DSSTox Substance ID:DTXSID001120865
ChEMBL ID:CHEMBL111319

Synonyms:CHEMBL111319;SCHEMBL6337937;DTXSID001120865;BDBM50147435;454219-13-7;N''-[4-(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl]-N,N-dimethylsulfamide;N'-[4-[2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]ethyl]phenyl]-N,N-dimethylsulfamide

Suppliers and Price of N''-[4-(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl]-N,N-dimethylsulfamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N''-[4-(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl]-N,N-dimethylsulfamide

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:397.1226905
Heavy Atom Count:26
Complexity:504

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)S(=O)(=O)NC1=CC=C(C=C1)CCNCC(C2=CC(=CC=C2)Cl)O
Isomeric SMILES:CN(C)S(=O)(=O)NC1=CC=C(C=C1)CCNC[C@@H](C2=CC(=CC=C2)Cl)O

Technology Process of N''-[4-(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl]-N,N-dimethylsulfamide

There total 6 articles about N''-[4-(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl]-N,N-dimethylsulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 727989-46-0
dimethylamino-1-sulfonic acid (4-{2-[5(R)-(3-chloro-phenyl)-2-oxo-oxazolidin-3-yl]-2-ethyl}-phenyl)-amide

: 454219-13-7
N'-[4-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-phenyl]-N,N-dimethyl-sulfamide

Guidance literature:: With potassium hydroxide; In ethanol; at 80 ℃;
DOI:10.1016/j.bmcl.2004.03.089

Reference yield:

: 24954-67-4
2-(p-nitrophenyl)ethylamine

: 454219-13-7
N'-[4-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-phenyl]-N,N-dimethyl-sulfamide

Guidance literature:: Multi-step reaction with 5 steps

1: N,O-bis(trimethylsilyl)amide / dimethylsulfoxide / 75 °C

2: CH₂Cl₂

3: 100 percent / SnCl₂*2H₂O; EtOH / Heating

4: pyridine / CH₂Cl₂ / -35 - 60 °C

5: KOH / ethanol / 80 °C

With pyridine; potassium hydroxide; ethanol; N,O-bis-(trimethylsilyl)-acetamide; tin(ll) chloride; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2004.03.089

Reference yield:

: 20697-04-5,53631-04-2,115648-90-3,62600-71-9
(R)-meta-chlorostyrene oxide

: 454219-13-7
N'-[4-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-phenyl]-N,N-dimethyl-sulfamide

Guidance literature:: Multi-step reaction with 5 steps

1: N,O-bis(trimethylsilyl)amide / dimethylsulfoxide / 75 °C

2: CH₂Cl₂

3: 100 percent / SnCl₂*2H₂O; EtOH / Heating

4: pyridine / CH₂Cl₂ / -35 - 60 °C

5: KOH / ethanol / 80 °C

With pyridine; potassium hydroxide; ethanol; N,O-bis-(trimethylsilyl)-acetamide; tin(ll) chloride; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2004.03.089