2-Oxazolidinone, 3-[(2R,3S,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-hydroxy-2-meth yl-1-oxo-4-hexenyl]-4-(phenylmethyl)-, (4R)-

Base Information

Chemical Name:2-Oxazolidinone, 3-[(2R,3S,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-hydroxy-2-meth yl-1-oxo-4-hexenyl]-4-(phenylmethyl)-, (4R)-
CAS No.:455901-38-9
Molecular Formula:C33H39NO5Si
Molecular Weight:557.762
Hs Code.:
Mol file:455901-38-9.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Oxazolidinone, 3-[(2R,3S,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-hydroxy-2-meth yl-1-oxo-4-hexenyl]-4-(phenylmethyl)-, (4R)-

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Technology Process of 2-Oxazolidinone, 3-[(2R,3S,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-hydroxy-2-meth yl-1-oxo-4-hexenyl]-4-(phenylmethyl)-, (4R)-

There total 3 articles about 2-Oxazolidinone, 3-[(2R,3S,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-hydroxy-2-meth yl-1-oxo-4-hexenyl]-4-(phenylmethyl)-, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 101711-78-8,131685-53-5
(3R)-3-propionyl-4-benzyloxazolidin-2-one

: 131380-48-8
(E)-4-(t-butyldiphenylsilyl)oxy-2-butenal

: 455901-38-9
(4E)-1-[(4R)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl)](3S,2R)-6-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-3-hydroxy-2-methylhex-4-en-1-one

Guidance literature:: With (n-C₄H₉)BOSO₂CF₃; triethylamine;
DOI:10.1002/1521-3773(20020517)41:10<1737::AID-ANIE1737>3.0.CO;2-4

Reference yield:

: 87770-83-0
(Z)-4-((tert-butyldiphenylsilyl)oxy)but-2-en-1-ol

: 455901-38-9
(4E)-1-[(4R)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl)](3S,2R)-6-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-3-hydroxy-2-methylhex-4-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 6.35 g / Et₃N; SO₃; pyridine / CH₂Cl₂; dimethylsulfoxide / 0 - 20 °C

2.1: Bu₂BOTf; TEA / CH₂Cl₂ / 0 °C

2.2: 89 percent / CH₂Cl₂ / -78 - 0 °C

With pyridine; di-n-butylboryl trifluoromethanesulfonate; TEA; sulfur trioxide; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ja037643+

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 455901-38-9
(4E)-1-[(4R)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl)](3S,2R)-6-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-3-hydroxy-2-methylhex-4-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran

1.2: tetrahydrofuran / 1.5 h

2.1: 6.35 g / Et₃N; SO₃; pyridine / CH₂Cl₂; dimethylsulfoxide / 0 - 20 °C

3.1: Bu₂BOTf; TEA / CH₂Cl₂ / 0 °C

3.2: 89 percent / CH₂Cl₂ / -78 - 0 °C

With pyridine; n-butyllithium; di-n-butylboryl trifluoromethanesulfonate; TEA; sulfur trioxide; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ja037643+