MK-0493 free base

Base Information

Chemical Name:MK-0493 free base
CAS No.:455956-93-1
Molecular Formula:C30H38ClF2N3O2
Molecular Weight:546.1
Hs Code.:
UNII:7LM4TSZ81B
Wikidata:Q27268535
Mol file:455956-93-1.mol

Synonyms:MK 0493;MK-0493;MK0493;N-1-(2-(1-(tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)-5-chlorophenyl)ethyl)acetamide

Suppliers and Price of MK-0493 free base

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of MK-0493 free base

Chemical Property:

PSA：52.65000
LogP:6.30210
XLogP3:4.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:545.2620615
Heavy Atom Count:38
Complexity:831

Purity/Quality:: ≥98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=C(C=CC(=C1)Cl)C2CCN(CC2)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C)NC(=O)C
Isomeric SMILES:C[C@@H](C1=C(C=CC(=C1)Cl)C2CCN(CC2)C(=O)[C@@H]3CN(C[C@H]3C4=C(C=C(C=C4)F)F)C(C)(C)C)NC(=O)C

Technology Process of MK-0493 free base

There total 2 articles about MK-0493 free base which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₂₁ClN₂O

: 455956-93-1
N-{(1S)-1-[2-(1-{[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}piperidin-4-yl)-5-chlorophenyl]ethyl}-acetamide

Guidance literature:: (3S,4R)-N-tert-butyl-4-(2,4-difluoro-phenyl)-pyrrolidine-3-carboxylic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; at 40 ℃; for 0.5h;

C₁₅H₂₁ClN₂O; With triethylamine; In acetonitrile; at 5 - 20 ℃;