2-N-tert-butyl-3-(methoxymethylcarbamothioyl)pyridine-2,6-dicarboxamide

Base Information

Chemical Name:2-N-tert-butyl-3-(methoxymethylcarbamothioyl)pyridine-2,6-dicarboxamide
CAS No.:91285-82-4
Molecular Formula:C₁₄H₂₀N₄O₃S
Molecular Weight:324.404
Hs Code.:
NSC Number:382164
DSSTox Substance ID:DTXSID80393765

Synonyms:91285-82-4;NSC382164;DTXSID80393765;2-N-tert-butyl-3-(methoxymethylcarbamothioyl)pyridine-2,6-dicarboxamide;NSC-382164

Suppliers and Price of 2-N-tert-butyl-3-(methoxymethylcarbamothioyl)pyridine-2,6-dicarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-N-tert-butyl-3-(methoxymethylcarbamothioyl)pyridine-2,6-dicarboxamide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.236g/cm³
XLogP3:0.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:324.12561169
Heavy Atom Count:22
Complexity:436

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)NC(=O)C1=C(C=CC(=N1)C(=O)N)C(=S)NCOC

Technology Process of 2-N-tert-butyl-3-(methoxymethylcarbamothioyl)pyridine-2,6-dicarboxamide

There total 7 articles about 2-N-tert-butyl-3-(methoxymethylcarbamothioyl)pyridine-2,6-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5453-67-8
2,6-bis(methoxycarbonyl)pyridine

: 91285-82-4
3-(Methoxymethyl-thiocarbamoyl)-pyridine-2,6-dicarboxylic acid 6-amide 2-tert-butylamide

Guidance literature:: Multi-step reaction with 5 steps

1: KOH / methanol / 1 h

2: SOCl₂ / tetrahydrofuran / 20 °C

3: diethyl ether / 0 °C

4: conc. NH₄OH / 20 °C

5: 1.) THF, 0 deg C, 1 h; 2.) 0 deg C, 15 min, 1 equiv. of CH₃OCH₂N=C=S

With potassium hydroxide; ammonium hydroxide; thionyl chloride; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/S0040-4039(01)81179-5

Reference yield:

: 3739-94-4
2,6-Pyridinedicarbonyl dichloride

: 91285-82-4
3-(Methoxymethyl-thiocarbamoyl)-pyridine-2,6-dicarboxylic acid 6-amide 2-tert-butylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1 h / 0 °C

2: KOH / methanol / 1 h

3: SOCl₂ / tetrahydrofuran / 20 °C

4: diethyl ether / 0 °C

5: conc. NH₄OH / 20 °C

6: 1.) THF, 0 deg C, 1 h; 2.) 0 deg C, 15 min, 1 equiv. of CH₃OCH₂N=C=S

With potassium hydroxide; ammonium hydroxide; thionyl chloride; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/S0040-4039(01)81179-5

Reference yield:

: 499-83-2
Pyridine-2,6-dicarboxylic acid

: 91285-82-4
3-(Methoxymethyl-thiocarbamoyl)-pyridine-2,6-dicarboxylic acid 6-amide 2-tert-butylamide

Guidance literature:: Multi-step reaction with 7 steps

1: THF / 24 h / Heating

2: 1 h / 0 °C

3: KOH / methanol / 1 h

4: SOCl₂ / tetrahydrofuran / 20 °C

5: diethyl ether / 0 °C

6: conc. NH₄OH / 20 °C

7: 1.) THF, 0 deg C, 1 h; 2.) 0 deg C, 15 min, 1 equiv. of CH₃OCH₂N=C=S

With tetrahydrofuran; potassium hydroxide; ammonium hydroxide; thionyl chloride; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/S0040-4039(01)81179-5