(3R,5R,8aR)-3-butyl-5-propyloctahydroindolizine

Base Information

• Chemical Name: (3R,5R,8aR)-3-butyl-5-propyloctahydroindolizine
• CAS No.: 72120-43-5
• Molecular Formula: C₁₅H₂₉N
• Molecular Weight: 223.402
• Mol file: 72120-43-5.mol

Synonyms:

Chemical Property of (3R,5R,8aR)-3-butyl-5-propyloctahydroindolizine

Chemical Property:

• Vapor Pressure: 0.0064mmHg at 25°C
• Boiling Point: 271.6°C at 760 mmHg
• Flash Point: 107.9°C
• Density: 0.9g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,5R,8aR)-3-butyl-5-propyloctahydroindolizine

There total 290 articles about (3R,5R,8aR)-3-butyl-5-propyloctahydroindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(2R,6R,E)-benzyl 2-(3-oxohept-1-enyl)-6-propylpiperidine-1-carboxylate (1226808-32-7) → (-)-indolizidine 223AB (67217-85-0,72120-43-5) + (5Z,9Z)-3-Butyl-5-propylindolizidine (72120-43-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 2844.39 Torr;

DOI:10.1039/b927007h

Reference yield: 91.0%

(2R,6R,E)-benzyl 2-(3-oxohept-1-enyl)-6-propylpiperidine-1-carboxylate (1226808-32-7) → (-)-indolizidine 223AB (67217-85-0,72120-43-5) + (5Z,9Z)-3-Butyl-5-propylindolizidine (72120-43-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 2844.39 Torr;

DOI:10.1039/b927007h

Reference yield: 90.0%

(3R,5R,8aS)-3-butyl-5-propyl-1,2,3,5,8,8a-hexahydroindolizine → (-)-indolizidine 223AB (67217-85-0,72120-43-5)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 3h; under 760.051 Torr;

DOI:10.1002/ejoc.201901494

upstream raw materials:

1-(5-Butyl-2-pyrrolidinylidene)-2-heptanone

(3R*,5S*,8aS*)-3-Butyl-5-propyloctahydroindolizin-7-one

(3R*,5R*,8aS*)-3-Butyl-5-propyloctahydroindolizin-7-one

rel-<2S,6S,2(3R)>-N-<(benzyloxy)carbonyl>-2-<3-<(methylsulfonyl)oxy>heptyl>-6-propylpiperidine