N-(4-Ethynylphenyl)-N-(pyridin-2-yl)pyridin-2-amine

Base Information

Chemical Name:N-(4-Ethynylphenyl)-N-(pyridin-2-yl)pyridin-2-amine
CAS No.:467238-88-6
Molecular Formula:C18H13N3
Molecular Weight:271.321
Hs Code.:
DSSTox Substance ID:DTXSID50514288
Nikkaji Number:J1.724.443D
Wikidata:Q82374520
Mol file:467238-88-6.mol

Synonyms:467238-88-6;N-(4-Ethynylphenyl)-N-(pyridin-2-yl)pyridin-2-amine;DTXSID50514288

Suppliers and Price of N-(4-Ethynylphenyl)-N-(pyridin-2-yl)pyridin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-Ethynylphenyl)-N-(pyridin-2-yl)pyridin-2-amine

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:271.110947427
Heavy Atom Count:21
Complexity:346

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C#CC1=CC=C(C=C1)N(C2=CC=CC=N2)C3=CC=CC=N3

Technology Process of N-(4-Ethynylphenyl)-N-(pyridin-2-yl)pyridin-2-amine

There total 3 articles about N-(4-Ethynylphenyl)-N-(pyridin-2-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1066-54-2
trimethylsilylacetylene

: 467238-86-4
N-(4-bromophenyl)-N-(pyridin-2-yl)pyridin-2-amine

: 467238-88-6
(4-(2,2'-dipyridylamino)phenyl)acetylene

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; at 80 - 100 ℃; for 12h;
DOI:10.1016/S0040-4039(02)00660-3

Reference yield:

: 1202-34-2
di(pyridin-2-yl)amine

: 467238-88-6
(4-(2,2'-dipyridylamino)phenyl)acetylene

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / KOH; CuSO₄ / 4 h / 210 - 220 °C

2: Pd(PPh₃)4; CuI; NEt₃ / 12 h / 80 - 100 °C

With potassium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(II) sulfate; triethylamine; 1: Ullman condensation / 2: Sonogashira coupling reaction;
DOI:10.1016/S0040-4039(02)00660-3

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 467238-88-6
(4-(2,2'-dipyridylamino)phenyl)acetylene

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / KOH; CuSO₄ / 4 h / 210 - 220 °C

2: Pd(PPh₃)4; CuI; NEt₃ / 12 h / 80 - 100 °C

With potassium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(II) sulfate; triethylamine; 1: Ullman condensation / 2: Sonogashira coupling reaction;
DOI:10.1016/S0040-4039(02)00660-3