4,5-Diphenyloxazole

Base Information

• Chemical Name: 4,5-Diphenyloxazole
• CAS No.: 4675-18-7
• Molecular Formula: C15H11NO
• Molecular Weight: 221.258
• Hs Code.: 2934999090
• Mol file: 4675-18-7.mol

Synonyms:Oxazole, 4,5-diphenyl-;Oxazole,4,5-diphenyl;4,5-Diphenyloxazole;

Chemical Property of 4,5-Diphenyloxazole

Chemical Property:

• Melting Point: 44°C
• Refractive Index: 1.6283 (estimate)
• Boiling Point: 362.31°C (rough estimate)
• PSA: 26.03000
• Density: 1.0966 (rough estimate)
• LogP: 4.00860

Purity/Quality:

97% ^*data from raw suppliers

4,5-Diphenyloxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-Diphenyloxazole

There total 19 articles about 4,5-Diphenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-methylthio-4,5-diphenyl-1,3-oxazole (14725-35-0) → 4,5-diphenyloxazole (4675-18-7)

Guidance literature:

With triethylsilane; palladium 10% on activated carbon; In tetrahydrofuran; at 0 - 60 ℃; for 20.25h; chemoselective reaction;

DOI:10.1021/ol2026813

Reference yield: 83.0%

2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) + formamide (77287-34-4,77287-35-5,60100-09-6) → 4,5-diphenyloxazole (4675-18-7)

Guidance literature:

With sulfuric acid; In xylene; for 14h; Heating;

DOI:10.1055/s-1998-6093

Reference yield: 78.0%

N-(2-oxo-1,2-diphenylethyl)formamide (97195-28-3) → 4,5-diphenyloxazole (4675-18-7)

Guidance literature:

With iodine; triethylamine; triphenylphosphine; In dichloromethane; for 16h;

DOI:10.1016/j.tet.2004.03.037

upstream raw materials:

2-oxo-1,2-diphenylethyl formate

2-hydroxy-2-phenylacetophenone

formamide

Desyl chloride

Downstream raw materials:

(4,5-diphenyl-oxazol-2-yl)-phenyl-methanol

3-methyl-4,5-diphenyl-oxazolium; iodide

4,5-bis-(4-nitro-phenyl)-oxazole

4,4'-oxazole-4,5-diyl-bis-benzenesulfonamide