(1R)-1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: (1R)-1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 47145-36-8
• Molecular Formula: C18H21NO2
• Molecular Weight: 283.37
• DSSTox Substance ID: DTXSID60428120
• Nikkaji Number: J1.635.630A
• Wikidata: Q82240903
• Mol file: 47145-36-8.mol

Synonyms:47145-36-8;AC1OFX65;(1R)-1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline;DTXSID60428120;(R)-1-Benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property of (1R)-1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 283.157228913
• Heavy Atom Count: 21
• Complexity: 316

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C2C(NCCC2=C1)CC3=CC=CC=C3)OC
• Isomeric SMILES: COC1=C(C=C2[C@H](NCCC2=C1)CC3=CC=CC=C3)OC

Technology Process of (1R)-1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 10 articles about (1R)-1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(R)-1-Benzyl-6,7-dimethoxy-2-((R)-toluene-4-sulfinyl)-1,2,3,4-tetrahydro-isoquinoline (392662-77-0) → (1S)-1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (47145-36-8)

Guidance literature:

With hydrogenchloride; In ethanol; at 0 ℃; for 0.0833333h;

DOI:10.1016/S0040-4039(01)01854-8

Reference yield: 85.0%

(1S)-1,2,3,4-tetrahydro-1-benzoyl-6,7-dimethoxy-2-<((R)-1-phenylethyl)carbamoyl>isoquinoline (120034-55-1) → (1S)-1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (47145-36-8)

Guidance literature:

With sodium pentanolate; In pentan-1-ol; for 2h; Heating;

DOI:10.1021/jo00274a044

Reference yield: 79.0%

(-)-(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol (120142-61-2) → (1S)-1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (47145-36-8)

Guidance literature:

With perchloric acid; hydrogen; palladium on activated charcoal; In acetic acid; at 70 ℃; for 36h;

DOI:10.1021/jo00274a044

upstream raw materials:

(-)-(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol

(1S)-1,2,3,4-tetrahydro-1-benzoyl-6,7-dimethoxy-2-<((R)-1-phenylethyl)carbamoyl>isoquinoline

(R)-1-Benzyl-6,7-dimethoxy-2-((R)-toluene-4-sulfinyl)-1,2,3,4-tetrahydro-isoquinoline

phenylacetaldehyde