L-Alaninamide, N-[(2S,3S)-3-amino-4-(4-carboxyphenyl)-2-mercapto-1-oxobutyl]-3-[1,1' -biphenyl]-4-yl-L-alanyl-3-benzo[b]thien-3-yl-N-(phenylmethyl)-

Base Information

Chemical Name:L-Alaninamide, N-[(2S,3S)-3-amino-4-(4-carboxyphenyl)-2-mercapto-1-oxobutyl]-3-[1,1' -biphenyl]-4-yl-L-alanyl-3-benzo[b]thien-3-yl-N-(phenylmethyl)-
CAS No.:473259-84-6
Molecular Formula:C44H42N4O5S2
Molecular Weight:770.973
Hs Code.:

L-Alaninamide,
N-[(2S,3S)-3-amino-4-(4-carboxyphenyl)-2-mercapto-1-oxobutyl]-3-[1,1'
-biphenyl]-4-yl-L-alanyl-3-benzo[b]thien-3-yl-N-(phenylmethyl)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Alaninamide, N-[(2S,3S)-3-amino-4-(4-carboxyphenyl)-2-mercapto-1-oxobutyl]-3-[1,1' -biphenyl]-4-yl-L-alanyl-3-benzo[b]thien-3-yl-N-(phenylmethyl)-

Chemical Property:

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Technology Process of L-Alaninamide, N-[(2S,3S)-3-amino-4-(4-carboxyphenyl)-2-mercapto-1-oxobutyl]-3-[1,1' -biphenyl]-4-yl-L-alanyl-3-benzo[b]thien-3-yl-N-(phenylmethyl)-

There total 11 articles about L-Alaninamide, N-[(2S,3S)-3-amino-4-(4-carboxyphenyl)-2-mercapto-1-oxobutyl]-3-[1,1' -biphenyl]-4-yl-L-alanyl-3-benzo[b]thien-3-yl-N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 473259-71-1
4-[2-tert-butoxycarbonylamino-3-carboxy-3-(4-methoxybenzylsulfanyl)propyl]benzoic acid tert-butyl ester

: 473260-02-5
2-amino-N-(2-benzo[b]thiophen-3-yl-1-benzylcarbamoyl-ethyl)-3-biphenyl-4-yl-propionamide

: 473259-84-6
4-{(2S)-2-amino-3-[1-(2S)-2-benzo[b]thiophen-3-yl-1-benzylcarbamoylethylcarbamoyl-(2S)-2-biphenyl-4-yl-ethylcarbamoyl]-3(S)-sulfanylpropyl}benzoic acid

Guidance literature:: 4-[2-tert-butoxycarbonylamino-3-carboxy-3-(4-methoxybenzylsulfanyl)propyl]benzoic acid tert-butyl ester; 2-amino-N-(2-benzo[b]thiophen-3-yl-1-benzylcarbamoyl-ethyl)-3-biphenyl-4-yl-propionamide; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

With dimethylsulfide; hydrogen fluoride; In methoxybenzene; at 0 ℃; for 1h;
DOI:10.1021/jm0300680

Reference yield:

: 119273-61-9,128779-47-5,147923-08-8
N-tert-butoxycarbonyl-p-phenyl-L-phenylalanine

: 473259-84-6
4-{(2S)-2-amino-3-[1-(2S)-2-benzo[b]thiophen-3-yl-1-benzylcarbamoylethylcarbamoyl-(2S)-2-biphenyl-4-yl-ethylcarbamoyl]-3(S)-sulfanylpropyl}benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: Bop; iPr₂NEt

2.1: TFA

3.1: Bop; iPr₂NEt / dimethylformamide / 3 h / 20 °C

3.2: 27 mg / HF; Me₂S / methoxybenzene / 1 h / 0 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm0300680

Reference yield:

: 100-46-9
benzylamine

: 473259-84-6
4-{(2S)-2-amino-3-[1-(2S)-2-benzo[b]thiophen-3-yl-1-benzylcarbamoylethylcarbamoyl-(2S)-2-biphenyl-4-yl-ethylcarbamoyl]-3(S)-sulfanylpropyl}benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: Bop; iPr₂NEt / CH₂Cl₂ / 3 h / 20 °C

2.1: TFA / CH₂Cl₂ / 3 h / 0 - 20 °C

3.1: Bop; iPr₂NEt

4.1: TFA

5.1: Bop; iPr₂NEt / dimethylformamide / 3 h / 20 °C

5.2: 27 mg / HF; Me₂S / methoxybenzene / 1 h / 0 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0300680