Technology Process of a-L-ido-4-Octulopyranosonic acid,2,3-dideoxy-3-(4-hydroxyphenyl)-, g-lactone (9CI)
There total 5 articles about a-L-ido-4-Octulopyranosonic acid,2,3-dideoxy-3-(4-hydroxyphenyl)-, g-lactone (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C28H32O8;
With
palladium 10% on activated carbon; hydrogen;
In
methanol; ethyl acetate;
for 30h;
under 3040.2 Torr;
With
trifluoroacetic acid;
at 20 ℃;
for 18h;
diastereoselective reaction;
DOI:10.1016/j.tetlet.2021.153072
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 1 h / 0 - 20 °C
2.1: toluene / 110 h / 125 °C / Inert atmosphere
3.1: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 30 h / 3040.2 Torr
3.2: 18 h / 20 °C
With
palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; Dess-Martin periodane;
In
methanol; dichloromethane; ethyl acetate; toluene;
2.1: |Wittig-Horner Reaction;
DOI:10.1016/j.tetlet.2021.153072
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 2.5 h / 0 - 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 1 h / 0 - 20 °C
4.1: toluene / 110 h / 125 °C / Inert atmosphere
5.1: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 30 h / 3040.2 Torr
5.2: 18 h / 20 °C
With
n-butyllithium; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; Dess-Martin periodane;
In
tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; toluene;
4.1: |Wittig-Horner Reaction;
DOI:10.1016/j.tetlet.2021.153072
