1-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE

Base Information

• Chemical Name: 1-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE
• CAS No.: 473732-66-0
• Molecular Formula: C10H11F4N
• Molecular Weight: 221.1946528
• Mol file: 473732-66-0.mol

Synonyms:

Chemical Property of 1-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

1-(3-Fluoro-4-(trifluoromethyl)phenyl)propan-1-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE

There total 5 articles about 1-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

→ 1-[3-fluoro-4-(trifluoromethyl)phenyl]propylamine (473732-66-0)

Guidance literature:

Reference yield:

1-(3-fluoro-4-trifluoromethyl-phenyl)-propan-1-one (237761-78-3) → 1-[3-fluoro-4-(trifluoromethyl)phenyl]propylamine (473732-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 16 h / 20 °C

2: H₂; NH₃ / Pd/C / methanol

With pyridine; ammonia; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/j.bmcl.2007.04.105

Reference yield:

1-(3-fluoro-4-trifluoromethyl-phenyl)-propan-1-one oxime → 1-[3-fluoro-4-(trifluoromethyl)phenyl]propylamine (473732-66-0)

Guidance literature:

With thiophene; ammonia; hydrogen; RaNi; In methanol;

DOI:10.1016/j.bmcl.2004.11.064

upstream raw materials:

1-(3-fluoro-4-trifluoromethyl-phenyl)-propan-1-one

Downstream raw materials:

C₂₃H₂₁F₄N₃O₄