1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid, 10-[2-[(carboxymethyl)amino]-2-oxoethyl]-, 1,4,7-tris(phenylmethyl) ester

Base Information

• Chemical Name: 1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid, 10-[2-[(carboxymethyl)amino]-2-oxoethyl]-, 1,4,7-tris(phenylmethyl) ester
• CAS No.: 473894-89-2
• Molecular Formula: C36H43N5O9
• Molecular Weight: 689.766
• Mol file: 473894-89-2.mol

Synonyms:

Chemical Property of 1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid, 10-[2-[(carboxymethyl)amino]-2-oxoethyl]-, 1,4,7-tris(phenylmethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of 1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid, 10-[2-[(carboxymethyl)amino]-2-oxoethyl]-, 1,4,7-tris(phenylmethyl) ester

There total 4 articles about 1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid, 10-[2-[(carboxymethyl)amino]-2-oxoethyl]-, 1,4,7-tris(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl N-({4,7,10-tris[(benzyloxy)carbonyl]-1,4,7,10-tetraazacyclododecan-1-yl} acetyl)glycinate (473894-88-1) → N-({4,7,10-tris[(benzyloxy)carbonyl]-1,4,7,10-tetraazacyclododecan-1-yl}acetyl)glycine (473894-89-2)

Guidance literature:

With sodium hydroxide;

DOI:10.1016/S0968-0896(03)00216-5

Reference yield:

1,4,7-tribenzyl 1,4,7,10-tetraazacyclododecane 1,4,7-tricarboxylate (138884-09-0) → N-({4,7,10-tris[(benzyloxy)carbonyl]-1,4,7,10-tetraazacyclododecan-1-yl}acetyl)glycine (473894-89-2)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOH

2: HBTU

3: NaOH

With sodium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;

DOI:10.1016/S0968-0896(03)00216-5

Reference yield:

1,4,7-tris-(benzyloxycarbonyl)-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane (400894-66-8) → N-({4,7,10-tris[(benzyloxy)carbonyl]-1,4,7,10-tetraazacyclododecan-1-yl}acetyl)glycine (473894-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1: HBTU

2: NaOH

With sodium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;

DOI:10.1016/S0968-0896(03)00216-5

upstream raw materials:

ethyl N-({4,7,10-tris[(benzyloxy)carbonyl]-1,4,7,10-tetraazacyclododecan-1-yl} acetyl)glycinate

1,4,7-tribenzyl 1,4,7,10-tetraazacyclododecane 1,4,7-tricarboxylate

1,4,7-tris-(benzyloxycarbonyl)-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane

1,4,7-tris-(benzyloxycarbonyl)-10-(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

Downstream raw materials:

10-{[({tert-butoxycarbonylmethyl-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-1,4,7,10tetraaza-cyclododecane-1,4,7-tricarboxylic acid tribenzyl ester

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