1-Iodo-3-MethoxyMethoxy-benzene

Base Information

• Chemical Name: 1-Iodo-3-MethoxyMethoxy-benzene
• CAS No.: 474009-16-0
• Molecular Formula: C8H9IO2
• Molecular Weight: 264.063
• Mol file: 474009-16-0.mol

Synonyms:3-iodo-O-methoxymethylphenol;3-(methoxymethoxy)-1-iodobenzene;1-iodo-3-{[(methoxy)methyl]oxy}benzene;

Chemical Property of 1-Iodo-3-MethoxyMethoxy-benzene

Chemical Property:

• Boiling Point: 289.6±20.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.667±0.06 g/cm3(Predicted)
• LogP: 2.27390

Purity/Quality:

1-Iodo-3-methoxymethoxy-benzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Iodo-3-MethoxyMethoxy-benzene

There total 2 articles about 1-Iodo-3-MethoxyMethoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-Iodophenol (626-02-8) + chloromethyl methyl ether (107-30-2) → 3-(methoxymethoxy)-1-iodobenzene (474009-16-0)

Guidance literature:

3-Iodophenol; With sodium hydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

chloromethyl methyl ether; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm1006929

Reference yield:

bromethyl methyl ether (13057-17-5) + 3-Iodophenol (626-02-8) → 3-(methoxymethoxy)-1-iodobenzene (474009-16-0)

Guidance literature:

3-Iodophenol; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

bromethyl methyl ether; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

Reference yield: 98.0%

3-(methoxymethoxy)-1-iodobenzene (474009-16-0) + 3,3-Dimethylbut-1-yne (917-92-0) → 1-(3,3-dimethylbut-1-yn-1-yl)-3-(methoxymethoxy)benzene

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 25 ℃; for 2h;

upstream raw materials:

3-Iodophenol

chloromethyl methyl ether

bromethyl methyl ether

Downstream raw materials:

C₁₃H₁₅F₃O₅

(E)-ethyl 2-(3-(methoxymethoxy)phenyl)-3-phenylpent-2-enoate

C₁₈H₂₀O₃

(8S,9S)-6'-methoxy-9-[3-(methoxymethoxy)phenyl]cinchonan