1,8-Naphthyridine, 2-chloro-3-(4-methoxyphenyl)-

Base Information

Chemical Name:1,8-Naphthyridine, 2-chloro-3-(4-methoxyphenyl)-
CAS No.:474266-27-8
Molecular Formula:C15H11ClN2O
Molecular Weight:270.718
Hs Code.:
DSSTox Substance ID:DTXSID10452718
Wikidata:Q82273513
Mol file:474266-27-8.mol

Synonyms:2-chloro-3-(4-methoxyphenyl)-1,8-naphthyridine;474266-27-8;1,8-Naphthyridine, 2-chloro-3-(4-methoxyphenyl)-;DTXSID10452718

Suppliers and Price of 1,8-Naphthyridine, 2-chloro-3-(4-methoxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1,8-Naphthyridine, 2-chloro-3-(4-methoxyphenyl)-

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:270.0559907
Heavy Atom Count:19
Complexity:294

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=C(N=C3C(=C2)C=CC=N3)Cl

Technology Process of 1,8-Naphthyridine, 2-chloro-3-(4-methoxyphenyl)-

There total 5 articles about 1,8-Naphthyridine, 2-chloro-3-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 477849-11-9
1,2-dihydro-3-(4-methoxyphenyl)-1,8-naphthyridin-2(1H)-one

: 474266-27-8
2-chloro-3-(p-methoxyphenyl)-1,8-naphthyridine

Guidance literature:: With trichlorophosphate; for 2h; Heating;
DOI:10.1081/SCC-120006009

Reference yield:

: C₁₅H₁₂N₂O₂

: 474266-27-8
2-chloro-3-(p-methoxyphenyl)-1,8-naphthyridine

Guidance literature:: With trichlorophosphate; for 6h; Heating;
DOI:10.1134/S1070363218060312

Reference yield:

: 7521-41-7
2-Aminonicotinaldehyde

: 474266-27-8
2-chloro-3-(p-methoxyphenyl)-1,8-naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / piperidine / 0.13 h / 20 °C

2: 75 percent / 2 N HCl; aq. NaNO₂ / 0.5 h / 20 °C

3: 85 percent / POCl₃ / 2 h / Heating

With piperidine; hydrogenchloride; sodium nitrite; trichlorophosphate;
DOI:10.1081/SCC-120006009