5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-(methoxymethyl)-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-

Base Information

Chemical Name:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-(methoxymethyl)-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-
CAS No.:47435-84-7
Molecular Formula:C17H20N2O5S
Molecular Weight:364.422
Hs Code.:
Mol file:47435-84-7.mol

Synonyms:

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Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-(methoxymethyl)-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-

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MSDS Files:: SDS file from LookChem

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Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-(methoxymethyl)-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-

There total 5 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-(methoxymethyl)-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-phenylacetamido-3-methoxymethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester

: 47435-84-7
4-methoxybenzyl 7-amino-3-methoxymethyl-3-cephem-4-carboxylate

Guidance literature:: With pyridine; phosphorus pentachloride; In dichloromethane; at 0 ℃; for 0.5h;

7-phenylacetamido-3-methoxymethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester; at 0 ℃; for 1.5 - 2h;

With methanol; at -40 - 0 ℃; for 1h;

Reference yield:

: 24773-28-2
(6R)-3-methoxymethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

: 47435-84-7
(6R)-7t-amino-3-methoxymethyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

Guidance literature:: With pyridine; phosphorus pentachloride;
DOI:10.1021/jm00284a007

Reference yield:

: 24670-44-8
(6R)-3-methoxymethyl-5ξ,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

: 47435-84-7
(6R)-7t-amino-3-methoxymethyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: AcCl, Na₂S₂O₄

2: PCl₅, Py

With pyridine; sodium dithionite; phosphorus pentachloride; acetyl chloride;
DOI:10.1021/jm00284a007