FAUC-365

Base Information

Chemical Name:FAUC-365
CAS No.:474432-66-1
Molecular Formula:C23H25Cl2N3OS
Molecular Weight:462.4351
Hs Code.:
Mol file:474432-66-1.mol

Synonyms:

Suppliers and Price of FAUC-365

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
FAUC-365
1mg
$ 39.00

Cayman Chemical
FAUC-365
5mg
$ 152.00

Cayman Chemical
FAUC-365
10mg
$ 243.00

ApexBio Technology
FAUC-365
10mg
$ 243.00

ApexBio Technology
FAUC-365
5mg
$ 152.00

AK Scientific
N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-1-benzothiophene-2-carboxamide
1mg
$ 147.00

Total 11 raw suppliers

Chemical Property of FAUC-365

Chemical Property:

Solubility.:insoluble in EtOH; insoluble in H2O; ≥5.79 mg/mL in DMSO

Purity/Quality:

97% ^*data from raw suppliers

FAUC-365 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description FAUC-365 is a dopamine D3 receptor antagonist (Ki = 0.5 nM). It is selective for dopamine D3 receptors over dopamine D1, D2L, D2S, and D4 receptors (Kis = 8.8, 3.6, 2.6, and 0.34 μM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2 (Kis = 0.36 and 2 μM, respectively). FAUC-365 (1-10 mg/kg) prevents memory impairment in the novel object recognition test in dopamine transporter knockdown (DAT-KD) mice when administered prior to object learning.

Technology Process of FAUC-365

There total 3 articles about FAUC-365 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 6314-28-9
benzo[b]thiophene-2-carboxylic acid

: 189061-44-7
4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butylamine

: 474432-66-1
FAUC 365

Guidance literature:: benzo[b]thiophene-2-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In chloroform; toluene; at 90 ℃; for 0.5h;

4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butylamine; With triethylamine; In chloroform; at 0 ℃; for 0.5h;
DOI:10.1021/jm025558r

Reference yield:

: 6314-28-9
benzo[b]thiophene-2-carboxylic acid

: 474432-66-1
FAUC 365

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 8 h

2: tetrahydrofuran / 1 h

In tetrahydrofuran;
DOI:10.1021/jm020952a