Cyclopropanamine, 1-(2,4-difluorophenyl)-

Base Information

• Chemical Name: Cyclopropanamine, 1-(2,4-difluorophenyl)-
• CAS No.: 474709-81-4
• Molecular Formula: C9H9F2N
• Molecular Weight: 169.174
• Mol file: 474709-81-4.mol

Synonyms:1-(2,4-difluorophenyl)-cyclopropylamine;6,7-difluoro-1-(2,4-difluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;3-Quinolinecarboxylicacid,1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo;1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid;6,7-difluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid;

Chemical Property of Cyclopropanamine, 1-(2,4-difluorophenyl)-

Chemical Property:

• Vapor Pressure: 0.282mmHg at 25°C
• Boiling Point: 203.1oC at 760 mmHg
• Flash Point: 91.5oC
• PSA: 26.02000
• Density: 1.283g/cm3
• LogP: 2.61290

Purity/Quality:

97% ^*data from raw suppliers

1-(2,4-Difluorophenyl)cyclopropanamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropanamine, 1-(2,4-difluorophenyl)-

There total 2 articles about Cyclopropanamine, 1-(2,4-difluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

2,4-difluorobenzonitrile (3939-09-1,103496-86-2) + ethylmagnesium bromide (925-90-6) → 1-(2,4-difluorophenyl)cyclopropan-1-amine (474709-81-4)

Guidance literature:

With titanium(IV) isopropylate; boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 12h;

Reference yield:

(2,4-difluorophenyl)acetonitrile (656-35-9) → 1-(2,4-difluorophenyl)cyclopropan-1-amine (474709-81-4)

Guidance literature:

Reference yield: 97.0%

1-(2,4-difluorophenyl)cyclopropan-1-amine (474709-81-4) + 1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid (1335210-23-5) → methyl 5-(1-(2,4-difluorophenyl)cyclopropylcarbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate (1616340-77-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; at 0 ℃; for 1h;

upstream raw materials:

(2,4-difluorophenyl)acetonitrile

2,4-difluorobenzonitrile

ethylmagnesium bromide

Downstream raw materials:

N₁-[1-(2,4-difluorophenyl)cyclopropyl]-2-fluoro-4-[6-(1-trityl-1H-4-pyrazolyl)imidazo[1,2-a]pyridin-3-yl]benzamide

methyl 5-(1-(2,4-difluorophenyl)cyclopropylcarbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

C₂₂H₂₁F₂N₃O₅

methyl 5-(1-(2,4-difluorophenyl)cyclopropylcarbamoyl)-1-(2,2-dihydroxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxyiate

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