Cyclopropanamine, 1-(3,4-difluorophenyl)-

Base Information

• Chemical Name: Cyclopropanamine, 1-(3,4-difluorophenyl)-
• CAS No.: 474709-85-8
• Molecular Formula: C9H9F2N
• Molecular Weight: 169.174
• Hs Code.: 2921309990
• Mol file: 474709-85-8.mol

Synonyms:1-(3,4-difluorophenyl)-cyclopropyl amine;trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl amine;1-(3,4-Difluorophenyl)-cyclopropanamine;

Chemical Property of Cyclopropanamine, 1-(3,4-difluorophenyl)-

Chemical Property:

• Vapor Pressure: 0.16mmHg at 25°C
• Boiling Point: 213.9oC at 760 mmHg
• Flash Point: 100oC
• PSA: 26.02000
• Density: 1.283g/cm3
• LogP: 2.61290

Purity/Quality:

97% ^*data from raw suppliers

1-(3,4-difluorophenyl)cyclopropan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropanamine, 1-(3,4-difluorophenyl)-

There total 2 articles about Cyclopropanamine, 1-(3,4-difluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

3,4-Difluorobenzonitrile (64248-62-0) + ethylmagnesium bromide (925-90-6) → 1-(3,4-difluorophenyl)cyclopropane-1-amine (474709-85-8)

Guidance literature:

3,4-Difluorobenzonitrile; ethylmagnesium bromide; With titanium(IV) isopropylate; In diethyl ether; at -78 ℃; for 0.166667h;

With boron trifluoride diethyl etherate; In diethyl ether; at -78 ℃; for 1h;

DOI:10.1016/j.ejmech.2017.06.062

Reference yield:

→ 1-(3,4-difluorophenyl)cyclopropane-1-amine (474709-85-8)

Guidance literature:

Reference yield:

1-(3,4-difluorophenyl)cyclopropane-1-amine (474709-85-8) + 2-fluoro-5-chlorosulfonylbenzoic acid (37098-75-2) → C16H11ClF3NO3S

Guidance literature:

1-(3,4-difluorophenyl)cyclopropane-1-amine; 2-fluoro-5-chlorosulfonylbenzoic acid; at 80 ℃; for 16h;

In toluene; at 110 ℃; for 2h;

DOI:10.1016/j.ejmech.2017.06.062

upstream raw materials:

3,4-Difluorobenzonitrile

ethylmagnesium bromide

Downstream raw materials:

N₁-[1-(3,4-difluorophenyl)-cyclopropyl]-2-fluoro-4-[6-(1-trityl-1H-4-pyrazolyl)imidazo[1,2-a]pyridin-3-yl]benzamide

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