[(4-chlorophenyl)-isoquinolin-1-yl-methyl] benzoate

Base Information

Chemical Name:[(4-chlorophenyl)-isoquinolin-1-yl-methyl] benzoate
CAS No.:54923-37-4
Molecular Formula:C23H16 Cl N O2
Molecular Weight:373.83
Hs Code.:2933499090
Mol file:54923-37-4.mol

Synonyms:1-Isoquinolinemethanol,a-(4-chlorophenyl)-, benzoate(ester) (9CI); 1-Isoquinolinemethanol, a-(p-chlorophenyl)-, benzoate (6CI); NSC 25450

Suppliers and Price of [(4-chlorophenyl)-isoquinolin-1-yl-methyl] benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
[(4-CHLOROPHENYL)-ISOQUINOLIN-1-YL-METHYL] BENZOATE 95.00%
5MG
$ 500.38

Total 5 raw suppliers

Chemical Property of [(4-chlorophenyl)-isoquinolin-1-yl-methyl] benzoate

Chemical Property:

Vapor Pressure:1.04E-11mmHg at 25°C
Melting Point:161.5-162.5 °C
Boiling Point:539.5°C at 760 mmHg
PKA:3.81±0.30(Predicted)
Flash Point:280.1°C
PSA：39.19000
Density:1.283g/cm³
LogP:5.83460

Purity/Quality:

99% ^*data from raw suppliers

[(4-CHLOROPHENYL)-ISOQUINOLIN-1-YL-METHYL] BENZOATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [(4-chlorophenyl)-isoquinolin-1-yl-methyl] benzoate

There total 4 articles about [(4-chlorophenyl)-isoquinolin-1-yl-methyl] benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 844-25-7,55839-33-3
2-benzoyl-1-cyano-1,2-dihydroisoquinoline

: 104-88-1
4-chlorobenzaldehyde

: 54923-37-4
1-(α-benzoyloxy-4-chloro-benzyl)-isoquinoline

Guidance literature:: With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In acetonitrile; for 0.0833333h; ultrasound sonication;

Reference yield:

: 844-25-7,55839-33-3
2-benzoyl-1-cyano-1,2-dihydroisoquinoline

: 591-51-5
phenyllithium

: 54923-37-4
1-(α-benzoyloxy-4-chloro-benzyl)-isoquinoline

Guidance literature:: With 1,4-dioxane; diethyl ether; at -10 ℃; und anschliessend mit aether.4-Chlor-benzaldehyd-Loesung;
DOI:10.1021/ja01538a041

Reference yield:

: 119-65-3
isoquinoline

: 54923-37-4
1-(α-benzoyloxy-4-chloro-benzyl)-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / triethylbenzylammonmium chloride / CH₂Cl₂; H₂O / 0.33 h / Irradiation; ultrasound sonication

2: 98 percent / 50percent aq. NaOH / triethylbenzylammonium chloride / acetonitrile / 0.08 h / ultrasound sonication

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; water; acetonitrile;