Indolin-7-ol

Base Information

• Chemical Name: Indolin-7-ol
• CAS No.: 4770-38-1
• Molecular Formula: C8H9NO
• Molecular Weight: 135.166
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60547042
• Wikidata: Q82425044
• Mol file: 4770-38-1.mol

Synonyms:Indolin-7-ol;4770-38-1;2,3-Dihydro-1H-indol-7-ol;7-Indolinol;7-hydroxyindoline;SCHEMBL108394;DTXSID60547042;MFCD11617214;AKOS006316377;SB66192;AC-27816;D82764;EN300-7055535;Q-102612

Chemical Property of Indolin-7-ol

Chemical Property:

• Boiling Point: 281.6±29.0 °C(Predicted)
• PKA: 10.72±0.20(Predicted)
• PSA: 32.26000
• Density: 1.196±0.06 g/cm3(Predicted)
• LogP: 1.49820
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 135.068413911
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

99% ^*data from raw suppliers

1H-INDOL-7-OL,2,3-DIHYDRO 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNC2=C1C=CC=C2O

Technology Process of Indolin-7-ol

There total 5 articles about Indolin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

pyrrolobenzoxazine-2,5-dione (847976-13-0) → 7-hydroxy-indoline (4770-38-1)

Guidance literature:

With hydrogenchloride; for 5h; Heating;

DOI:10.1016/j.tetlet.2004.12.023

Reference yield: 31.0%

7-Indolol (2380-84-9) → 7-hydroxy-indoline (4770-38-1)

Guidance literature:

With sodium cyanoborohydride; acetic acid; at 0 - 20 ℃; for 4.5h;

DOI:10.1021/acs.orglett.0c02128

Reference yield:

1-(2,3-Dihydro-1H-indol-7-yl)-ethanol (105205-61-6) → 7-hydroxy-indoline (4770-38-1)

Guidance literature:

With boron trifluoride diethyl etherate; dihydrogen peroxide; In dichloromethane; at 22 ℃; for 22h;

DOI:10.1016/S0040-4039(00)95902-1

upstream raw materials:

1-(2,3-Dihydro-1H-indol-7-yl)-ethanol

2-(2,3-Dihydro-1H-indol-7-yl)-propan-2-ol

pyrrolobenzoxazine-2,5-dione

7-Indolol

Downstream raw materials:

1-acetyl-2,3-dihydro-7-hydroxyindole

7-Indolol