1H-INDOL-7-OL,2,3-DIHYDRO

Base Information

• Chemical Name: 1H-INDOL-7-OL,2,3-DIHYDRO
• CAS No.: 4770-38-1
• Molecular Formula: C8H9NO
• Molecular Weight: 135.166
• Hs Code.: 2933990090
• Mol file: 4770-38-1.mol

Synonyms:Indolin-7-ol;2,3-dihydro-indol-7-ol;1H-Indol-7-ol,2,3-dihydro;7-Hydroxy-indolin;7-hydroxy-indoline;

Chemical Property of 1H-INDOL-7-OL,2,3-DIHYDRO

Chemical Property:

• Boiling Point: 281.6±29.0 °C(Predicted)
• PKA: 10.72±0.20(Predicted)
• PSA: 32.26000
• Density: 1.196±0.06 g/cm3(Predicted)
• LogP: 1.49820
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

1H-INDOL-7-OL,2,3-DIHYDRO 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-INDOL-7-OL,2,3-DIHYDRO

There total 5 articles about 1H-INDOL-7-OL,2,3-DIHYDRO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

pyrrolobenzoxazine-2,5-dione (847976-13-0) → 7-hydroxy-indoline (4770-38-1)

Guidance literature:

With hydrogenchloride; for 5h; Heating;

DOI:10.1016/j.tetlet.2004.12.023

Reference yield: 31.0%

7-Indolol (2380-84-9) → 7-hydroxy-indoline (4770-38-1)

Guidance literature:

With sodium cyanoborohydride; acetic acid; at 0 - 20 ℃; for 4.5h;

DOI:10.1021/acs.orglett.0c02128

Reference yield:

1-(2,3-Dihydro-1H-indol-7-yl)-ethanol (105205-61-6) → 7-hydroxy-indoline (4770-38-1)

Guidance literature:

With boron trifluoride diethyl etherate; dihydrogen peroxide; In dichloromethane; at 22 ℃; for 22h;

DOI:10.1016/S0040-4039(00)95902-1

upstream raw materials:

1-(2,3-Dihydro-1H-indol-7-yl)-ethanol

2-(2,3-Dihydro-1H-indol-7-yl)-propan-2-ol

pyrrolobenzoxazine-2,5-dione

7-Indolol

Downstream raw materials:

7-Indolol

1-acetyl-2,3-dihydro-7-hydroxyindole

Refernces

• 1、 Ishiyama, Kazunao,Yamada, Yasuhiro. "Convenient synthesis of 7-hydroxyindole". . p. 1021 - 1022. Retrieved 2007/10/03.
• 2、 Boger, Dale L.,Coleman, Robert S.. "Benzylic Hydroperoxide Rearrangement: Observations on a Viable and Convenient Alternative to the Baeyer-Villiger Rearrangement". . p. 5436 - 5439. Retrieved 2007/10/02.