1H-Pyrrole-1-carboxylic acid, 3-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-2,5-dihydro-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Pyrrole-1-carboxylic acid, 3-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-2,5-dihydro-, 1,1-dimethylethyl ester
CAS No.:477351-64-7
Molecular Formula:C27H37NO3Si
Molecular Weight:451.681
Hs Code.:
Mol file:477351-64-7.mol

Synonyms:

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Chemical Property of 1H-Pyrrole-1-carboxylic acid, 3-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-2,5-dihydro-, 1,1-dimethylethyl ester

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Technology Process of 1H-Pyrrole-1-carboxylic acid, 3-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-2,5-dihydro-, 1,1-dimethylethyl ester

There total 7 articles about 1H-Pyrrole-1-carboxylic acid, 3-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-2,5-dihydro-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 477351-63-6
allyl-{2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-allyl}-carbamic acid tert-butyl ester

: 477351-64-7
3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: Grubbs catalyst first generation; In dichloromethane; at 20 ℃;
DOI:10.1021/ja0208153

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 477351-64-7
3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 1 h

2: 90 percent / (PCy₃)2Cl₂Ru=CHPh / CH₂Cl₂ / 20 °C

With triethylamine; Grubbs catalyst first generation; In dichloromethane; 2: Grubbs metahtesis reaction;
DOI:10.1021/ja0208153

Reference yield:

: 61541-20-6
methyl 4-hydroxy-2-methylenebutanoate

: 477351-64-7
3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / imidazole / dimethylformamide / 0 - 20 °C

2.1: 90 percent / DIBAL-H / CH₂Cl₂ / 0.33 h / -78 °C

3.1: MsCl; Et₃N / CH₂Cl₂ / 2 h / 0 °C

3.2: 84 percent / CH₂Cl₂ / 20 °C

4.1: 100 percent / Et₃N / CH₂Cl₂ / 1 h

5.1: 90 percent / (PCy₃)2Cl₂Ru=CHPh / CH₂Cl₂ / 20 °C

With 1H-imidazole; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; Grubbs catalyst first generation; In dichloromethane; N,N-dimethyl-formamide; 5.1: Grubbs metahtesis reaction;
DOI:10.1021/ja0208153