Butanoic acid, 2-hydroxy-5-nitrophenyl ester

Base Information

• Chemical Name: Butanoic acid, 2-hydroxy-5-nitrophenyl ester
• CAS No.: 477559-68-5
• Molecular Formula: C10H11NO5
• Molecular Weight: 225.201
• Mol file: 477559-68-5.mol

Synonyms:

Chemical Property of Butanoic acid, 2-hydroxy-5-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butanoic acid, 2-hydroxy-5-nitrophenyl ester

There total 2 articles about Butanoic acid, 2-hydroxy-5-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1,2-dihydroxy-4-nitrobenzene (3316-09-4) + butyryl chloride (141-75-3) → 2-hydroxy-5-nitrophenylbutanoate (477559-68-5)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1248/cpb.52.501

Reference yield: 30.0%

→ 2-butyryloxy-5-nitrophenylbutanoate (477559-67-4) + 2-hydroxy-5-nitrophenylbutanoate (477559-68-5)

Guidance literature:

Reference yield: 99.0%

2-hydroxy-5-nitrophenylbutanoate (477559-68-5) → 5-amino-2-hydroxyphenylbutanoate (477559-70-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 0.5h;

DOI:10.1248/cpb.52.501

upstream raw materials:

1,2-dihydroxy-4-nitrobenzene

butyryl chloride

Downstream raw materials:

5-amino-2-hydroxyphenylbutanoate

Refernces

• 1、 -. "Novel retinoid derivatives and methods for producing said compounds and anti-cancer pharmaceutical composition comprising said compounds". . . Retrieved 2008/06/13.