3-Acetamidopyrazine-2-carboxamide

Base Information

• Chemical Name: 3-Acetamidopyrazine-2-carboxamide
• CAS No.: 71898-69-6
• Molecular Formula: C7H8N4O2
• Molecular Weight: 180.164
• NSC Number: 129581
• DSSTox Substance ID: DTXSID00299351
• Wikidata: Q82041701
• Mol file: 71898-69-6.mol

Synonyms:3-acetamidopyrazine-2-carboxamide;71898-69-6;NSC129581;DTXSID00299351;AKOS006277719;NSC-129581

Chemical Property of 3-Acetamidopyrazine-2-carboxamide

Chemical Property:

• Vapor Pressure: 1.76E-09mmHg at 25°C
• Boiling Point: 482.8°C at 760 mmHg
• Flash Point: 245.8°C
• Density: 1.411g/cm³
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 180.06472551
• Heavy Atom Count: 13
• Complexity: 219

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=NC=CN=C1C(=O)N

Technology Process of 3-Acetamidopyrazine-2-carboxamide

There total 4 articles about 3-Acetamidopyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-amino-3-pyrazinonitrile (25911-65-3) + acetic anhydride (108-24-7) → 2-acetylaminopyrazine-3-carboxamide (71898-69-6)

Guidance literature:

In acetic acid; for 3h;

Reference yield:

2-Cyano-3-<(dimethylaminomethylene)amino>pyrazine (34859-38-6) → 2-acetylaminopyrazine-3-carboxamide (71898-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂OH*HCl / ethanol / 0.67 h / Heating

2: 50 percent / acetic acid / 3 h

With hydroxylamine hydrochloride; In ethanol; acetic acid;

Reference yield:

2-aminopyrazine-3-carboxamide oxime (76952-35-7) → 2-acetylaminopyrazine-3-carboxamide (71898-69-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent

2: H₂O / 7 h / Heating

3: 50 percent / acetic acid / 3 h

With water; In acetic acid;

upstream raw materials:

2-amino-3-pyrazinonitrile

acetic anhydride

2-aminopyrazine-3-carboxamide oxime

4-aminopteridine 3-oxide

Downstream raw materials:

2-Methylpteridin-4(3H)-on