POLY-L-TRYPTOPHAN

Base Information

• Chemical Name: POLY-L-TRYPTOPHAN
• CAS No.: 27813-82-7
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.228
• Mol file: 27813-82-7.mol

Synonyms:Tryptophan,L-, peptides (8CI); Poly(L-tryptophan); Polytryptophan; Tryptophan homopolymer

Chemical Property of POLY-L-TRYPTOPHAN

Chemical Property:

• Boiling Point: 447.9°Cat760mmHg
• Flash Point: 224.7°C
• PSA: 79.11000
• Density: 1.362g/cm³
• LogP: 1.82260
• Storage Temp.: −20°C

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of POLY-L-TRYPTOPHAN

There total 259 articles about POLY-L-TRYPTOPHAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

DL-γ-glutamaldehydic acid dimethyl acetal (70380-01-7) + phenylhydrazine hydrochloride (59-88-1) → Trp (54-12-6,27732-43-0,80206-30-0,27813-82-7)

Guidance literature:

With sulfuric acid; In water; for 1h; Heating;

DOI:10.1246/bcsj.62.961

Reference yield: 70.0%

rac-3-(1H-indol-3-yl)-2-(benzoylamino)propionic acid methyl ester (104331-05-7) → Trp (54-12-6,27732-43-0,80206-30-0,27813-82-7)

Guidance literature:

In potassium hydroxide; hydrolysis;

DOI:10.1016/S0040-4039(00)81629-9

Reference yield:

N-{(4-{methyl[(4-nitrophenoxy)carbonyl]amino}benzyloxy)carbonyl}-L-tryptophan (402943-23-1) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + carbon dioxide (124-38-9,18923-20-1) + L-Tryptophan (73-22-3,27732-43-0,80206-30-0,27813-82-7) + (4-(methylamino)phenyl)methanol (181819-75-0)

Guidance literature:

With abzyme ST₅₁; water; In dimethyl sulfoxide; at 25 ℃; pH=9.0; Further Variations:; time dependence; Enzyme kinetics;

DOI:10.1039/b103971g

upstream raw materials:

α-(hydroxyimino)-β-(indol-3-yl)propionic acid

5-(3-indolylmethylene)hydantoin

formylamino-indol-3-ylmethyl-malonic acid

acetylamino-indol-3-ylmethyl-malonic acid

Downstream raw materials:

1-benzyl-β-carboline

N^α-(4-Phenylazo-benzyloxycarbonyl)-L-tryptophan

[(benzyloxy)carbonyl]glycyl-L-tryptophan

N^α-(2-Benzyloxyimino-4-methyl-valeryl)-L-tryptophan

Refernces

• 1、 Azuma, Masayuki,Kumagai, Shinya,Nishiya, Yoshiaki,Sumida, Yosuke,Yamada, Toshihide,Yamasaki, Masayuki. "Protein Engineering of d-Succinylase from Cupriavidus sp. for d-Amino Acid Synthesis and the Structural Implications". . p. 4770 - 4778. Retrieved 2021/08/30.
• 2、 Bunn, Brittney M,Xu, Mizhi,Webb, Chase M,Viswanathan, Rajesh. "Biocatalysts from cyanobacterial hapalindole pathway afford antivirulent isonitriles against MRSA". . . Retrieved 2021/04/26.