(3S)-3aβ,4,5,5a,9aβ,9bα-Hexahydro-3β,5aα,9-trimethylnaphtho[1,2-b]furan-2(3H)-one

Base Information

Chemical Name:(3S)-3aβ,4,5,5a,9aβ,9bα-Hexahydro-3β,5aα,9-trimethylnaphtho[1,2-b]furan-2(3H)-one
CAS No.:37905-06-9
Molecular Formula:C15H20O2
Molecular Weight:232.32
Hs Code.:
Mol file:37905-06-9.mol

Synonyms:6,11βH-Endesma-1,3-dien-6,13-olid;5αH,6,11β-Eudesm-1,3-dien-6,13-olid;Dien IV;(3S,3aS,5aS,9aS,9bS)-3,5a,9-Trimethyl-3a,4,5,5a,9a,9b-hexahydro-3H-naphtho[1,2-b]furan-2-one;feropodin;

Suppliers and Price of (3S)-3aβ,4,5,5a,9aβ,9bα-Hexahydro-3β,5aα,9-trimethylnaphtho[1,2-b]furan-2(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-3aβ,4,5,5a,9aβ,9bα-Hexahydro-3β,5aα,9-trimethylnaphtho[1,2-b]furan-2(3H)-one

Chemical Property:

Melting Point:93.5-96.5 °C
Boiling Point:362.1±31.0 °C(Predicted)
PSA：26.30000
Density:1.058±0.06 g/cm3(Predicted)
LogP:3.09650

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3S)-3aβ,4,5,5a,9aβ,9bα-Hexahydro-3β,5aα,9-trimethylnaphtho[1,2-b]furan-2(3H)-one

There total 5 articles about (3S)-3aβ,4,5,5a,9aβ,9bα-Hexahydro-3β,5aα,9-trimethylnaphtho[1,2-b]furan-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 865202-67-1
(3S,3aS,5aS,9aR,9bS)-8-hydroxy-3,5a,9-trimethyl-3a,4,5,5a,8,9,9a,9b-octahydro-3H-naphtho[1,2-b]furan-2-one

: 37905-06-9
(3S,3aS,5aS,9aR,9bS)-3,5a,9-trimethyl-3a,4,5,5a,9,9a,9b-hexahydro-3H-naphtho[1,2-b]furan-2-one

Guidance literature:: (3S,3aS,5aS,9aR,9bS)-8-hydroxy-3,5a,9-trimethyl-3a,4,5,5a,8,9,9a,9b-octahydro-3H-naphtho[1,2-b]furan-2-one; With 2,6-dimethylpyridine; trichlorophosphate; In dichloromethane; at 0 - 20 ℃; for 18h;

With potassium carbonate; lithium iodide; In N,N-dimethyl-formamide; at 70 ℃; for 18h;

Reference yield:

: (3S,3aS,5aS,9R/S,9aR,9bS)-3,5a,9-trimethyl-3a,5,5a,9,9a,9b-hexahydro-3H,4H-naphtho[1,2-b]furan-2,8-dione

: 37905-06-9
(3S,3aS,5aS,9aR,9bS)-3,5a,9-trimethyl-3a,4,5,5a,9,9a,9b-hexahydro-3H-naphtho[1,2-b]furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / LaCl₃*7H₂O; NaBH₄ / methanol / 18 h / 20 °C

2.1: 2,6-lutidine; phosphorus oxychloride / CH₂Cl₂ / 18 h / 0 - 20 °C

2.2: 30 percent / lithium iodide; potassium carbonate / dimethylformamide / 18 h / 70 °C

With 2,6-dimethylpyridine; lanthanum(III) chloride; sodium tetrahydroborate; trichlorophosphate; In methanol; dichloromethane;

Reference yield:

: 37905-06-9
(3S,3aS,5aS,9aR,9bS)-3,5a,9-trimethyl-3a,4,5,5a,9,9a,9b-hexahydro-3H-naphtho[1,2-b]furan-2-one

Guidance literature:: Ketolacton III (/BRN= 348563/), 1) Al-isopropylat/Isopropylalkohol --> epimeres Alkoholgemisch, 2) Al2O3 (mit 2percent Py. behandelt) <230grad, N2>;
DOI:10.1021/ja00907a030