Isozaleplon

Base Information

Chemical Name:Isozaleplon
CAS No.:478081-98-0
Molecular Formula:C17H15N5O
Molecular Weight:305.339
Hs Code.:9999999999
UNII:YP251266R0
DSSTox Substance ID:DTXSID50197297
Nikkaji Number:J2.815.515H
Wikidata:Q27294631
Mol file:478081-98-0.mol

Synonyms:Isozaleplon;478081-98-0;N-(3-(3-Cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)-N-ethylacetamide;n-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-n-ethylacetamide;UNII-YP251266R0;N-(3-(3-Cyanopyrazolo[1,5-alpha]pyrimidin-5-yl)phenyl)-N-ethylacetamide;YP251266R0;N-(3-(3-Cyanopyrazolo(1,5-a)pyrimidin-5-yl)phenyl)-N-ethylacetamide;N-(3-(3-Cyanopyrazolo(1,5-alpha)pyrimidin-5-yl)phenyl)-N-ethylacetamide;N-(3-{3-CYANOPYRAZOLO[1,5-A]PYRIMIDIN-5-YL}PHENYL)-N-ETHYLACETAMIDE;SCHEMBL3162849;DTXSID50197297;ZMUMYMWAIXXLIY-UHFFFAOYSA-N;CS-0452821;Q27294631;N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethyl-acetamide;N-Ethyl-N-[3-(3-cyanopyrazolo[1,5-a]pyrimidine-5-yl)phenyl]acetamide;N-(3-(3-CYANOPYRAZOLO(1,5-.ALPHA.)PYRIMIDIN-5-YL)PHENYL)-N-ETHYLACETAMIDE;Acetamide, N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethyl-;N-[3-(3-Cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide;Zaleplon RC B CIV (USP);Zaleplon Related Compound B

Suppliers and Price of Isozaleplon

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(3-(3-Cyanopyrazolo[1,5-α]pyrimidin-5-yl)phenyl)-N-ethylacetamide
10mg
$ 760.00

Total 3 raw suppliers

Chemical Property of Isozaleplon

Chemical Property:

Melting Point:203-205 °C
PSA：74.29000
Density:1.25±0.1 g/cm3(Predicted)
LogP:2.64078
XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:305.12766012
Heavy Atom Count:23
Complexity:487

Purity/Quality:

95% ^*data from raw suppliers

N-(3-(3-Cyanopyrazolo[1,5-α]pyrimidin-5-yl)phenyl)-N-ethylacetamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(C1=CC=CC(=C1)C2=NC3=C(C=NN3C=C2)C#N)C(=O)C
Uses (N-[3-(3-Cyanopyrazolo[1,5-alpha]pyrimidin-5-yl)phenyl]-N-ethylacetamide) is used in the synthesis of Zaleplon (Z145000), which is a selective non-benzodiazepine GABAA receptor agonist, and a sedative-hypnotic, almost entirely used for the management/treatment of insomnia.

Technology Process of Isozaleplon

There total 7 articles about Isozaleplon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1227694-96-3
N-[3-[3-(dimethylamine)-1-oxo-2-propenyl]phenyl]-N-ethyl-acetamide

: 16617-46-2
3-amino-4-cyano-2H-pyrazole

: 478081-98-0
N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)-N-ethylacetamide

: 151319-34-5
zaleplon

Guidance literature:: With formic acid; In water; at 10 - 40 ℃; for 3h; Product distribution / selectivity;

Reference yield: 81.9%

: 1224288-92-9
5-chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile

: 1224288-99-6
N-ethyI-N-(3-(4,4,5,5-tetramethyI-1,3,2-dioxaboroIan-2-yl)phenyI)acetamide

: 478081-98-0
N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)-N-ethylacetamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; at 100 ℃; for 10h;
DOI:10.3987/COM-09-S(S)129

Reference yield: 75.8%

: 1224288-95-2
5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

: 1224288-99-6
N-ethyI-N-(3-(4,4,5,5-tetramethyI-1,3,2-dioxaboroIan-2-yl)phenyI)acetamide

: 478081-98-0
N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)-N-ethylacetamide

Guidance literature:: 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile; With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; for 2h; Inert atmosphere; Sealed tube;

N-ethyI-N-(3-(4,4,5,5-tetramethyI-1,3,2-dioxaboroIan-2-yl)phenyI)acetamide; With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; at 20 ℃; Sealed tube;
DOI:10.3987/COM-09-S(S)129