1H-Pyrrole-2-carboxylic acid, 1-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-4-[[(1,1-dimethyleth oxy)carbonyl]amino]-

Base Information

Chemical Name:1H-Pyrrole-2-carboxylic acid, 1-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-4-[[(1,1-dimethyleth oxy)carbonyl]amino]-
CAS No.:478812-28-1
Molecular Formula:C₂₁H₂₃N₃O₆
Molecular Weight:413.43
Hs Code.:
Mol file:478812-28-1.mol

Synonyms:

Suppliers and Price of 1H-Pyrrole-2-carboxylic acid, 1-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-4-[[(1,1-dimethyleth oxy)carbonyl]amino]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1H-Pyrrole-2-carboxylic acid, 1-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-4-[[(1,1-dimethyleth oxy)carbonyl]amino]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-2-carboxylic acid, 1-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-4-[[(1,1-dimethyleth oxy)carbonyl]amino]-

There total 6 articles about 1H-Pyrrole-2-carboxylic acid, 1-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-4-[[(1,1-dimethyleth oxy)carbonyl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 478812-27-0
(2-trimethylsilyl)ethyl 4-[(t-butoxycarbonyl)amino]-1-(phthalimidopropyl)pyrrole-2-carboxylate

: 478812-28-1
4-[(t-butoxycarbonyl)amino]-1-(phthalimidopropyl)pyrrole-2-carboxylic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ja021011q

Reference yield:

: 35302-72-8
pyrrol-2-yl trichloromethyl ketone

: 478812-28-1
4-[(t-butoxycarbonyl)amino]-1-(phthalimidopropyl)pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / nitric acid / acetic anhydride / 6 h / 20 °C

2: 92 percent / Na / tetrahydrofuran / 6 h

3: H₂ / Pd/C / ethanol; ethyl acetate / 8 h / 25858.1 Torr

4: 29.8 g / NaHCO₃ / H₂O; ethyl acetate / 4 h

5: 65 percent / tetrabutylammonium iodide; potassium carbonate / acetone / 24 h / Heating

6: 92 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0 - 20 °C

With tetrabutyl ammonium fluoride; hydrogen; nitric acid; sodium; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; acetic anhydride; ethyl acetate; acetone;
DOI:10.1021/ja021011q

Reference yield:

: 53391-50-7
2,2,2-trichloro-1-(4-nitro-1H-pyrrol-2-yl)ethan-1-one

: 478812-28-1
4-[(t-butoxycarbonyl)amino]-1-(phthalimidopropyl)pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / Na / tetrahydrofuran / 6 h

2: H₂ / Pd/C / ethanol; ethyl acetate / 8 h / 25858.1 Torr

3: 29.8 g / NaHCO₃ / H₂O; ethyl acetate / 4 h

4: 65 percent / tetrabutylammonium iodide; potassium carbonate / acetone / 24 h / Heating

5: 92 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0 - 20 °C

With tetrabutyl ammonium fluoride; hydrogen; sodium; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate; acetone;
DOI:10.1021/ja021011q