tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

Chemical Name:tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:478837-18-2
Molecular Formula:C12H21NO3
Molecular Weight:227.304
Hs Code.:
Mol file:478837-18-2.mol

Synonyms:tert-butyl exo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;(1R,3R,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester;3a-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid t-butyl ester;tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;3-exo-3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester;(3-endo)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;Boc-pseudotropine;(1R,3S,5S)-3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester;(cis)-3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester;

Suppliers and Price of tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl3-Hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
500mg
$ 130.00

Matrix Scientific
tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
10g
$ 1170.00

Matrix Scientific
tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
5g
$ 810.00

Matrix Scientific
tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
1g
$ 316.00

Crysdot
tert-Butyl3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 95+%
25g
$ 563.00

ChemScene
tert-Butyl3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate ≥97.0%
25g
$ 606.00

ChemScene
tert-Butyl3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate ≥97.0%
10g
$ 307.00

ChemScene
tert-Butyl3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate ≥97.0%
1g
$ 55.00

ChemScene
tert-Butyl3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate ≥97.0%
5g
$ 170.00

Chemenu
tert-Butyl3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 95%
10g
$ 288.00

Total 13 raw suppliers

Chemical Property of tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

Chemical Property:

PSA：49.77000
LogP:1.84710
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-Hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 4 articles about tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 185099-67-6
Boc-tropinone

: 478837-18-2
3-exo-hydroxy-8-azabicyclo[3.2.1]octane-8carboxylic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; ethanol; at 20 ℃; for 1h;

Reference yield:

: 7432-11-3
8-azabicyclo[3.2.1]octan-3-ol

: 24424-99-5
di-tert-butyl dicarbonate

: 478837-18-2
3-exo-hydroxy-8-azabicyclo[3.2.1]octane-8carboxylic acid tert-butyl ester

Guidance literature:: With sodium hydroxide; In water; acetonitrile;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 478837-18-2
3-exo-hydroxy-8-azabicyclo[3.2.1]octane-8carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 6 h / 20 - 30 °C

2: sodium tetrahydroborate / methanol / 0.5 h / 0 - 10 °C

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;