2-METHYLPROYL 2-PYRIDYL KETONE

Base Information

• Chemical Name: 2-METHYLPROYL 2-PYRIDYL KETONE
• CAS No.: 6952-53-0
• Molecular Formula: C10H13 N O
• Molecular Weight: 163.219
• Hs Code.: 2933399090
• Mol file: 6952-53-0.mol

Synonyms:Isobutyl2-pyridyl ketone; NSC 62100

Chemical Property of 2-METHYLPROYL 2-PYRIDYL KETONE

Chemical Property:

• Vapor Pressure: 0.0349mmHg at 25°C
• Boiling Point: 241.9°C at 760 mmHg
• PKA: 2.98±0.10(Predicted)
• Flash Point: 106.2°C
• PSA: 29.96000
• Density: 0.994g/cm³
• LogP: 2.31040

Purity/Quality:

99% ^*data from raw suppliers

3-Methyl-1-(pyridin-2-yl)butan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-METHYLPROYL 2-PYRIDYL KETONE

There total 4 articles about 2-METHYLPROYL 2-PYRIDYL KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-bromo-pyridine (109-04-6) + N-methoxy-N,3-dimethylbutanamide (147356-77-2) → 3-methyl-1-(pyridin-2-yl) butan-1-one (6952-53-0)

Guidance literature:

2-bromo-pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

N-methoxy-N,3-dimethylbutanamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1039/c9ob01655d

Reference yield: 30.0%

2-Cyanopyridine (100-70-9,1232006-36-8) + isobutylmagnesium bromide (926-62-5) → 3-methyl-1-(pyridin-2-yl) butan-1-one (6952-53-0)

Guidance literature:

2-Cyanopyridine; isobutylmagnesium bromide; In diethyl ether; at -15 - 20 ℃; for 3h;

With hydrogenchloride; water; In diethyl ether; at 20 ℃; for 0.25h;

DOI:10.1021/acs.orglett.8b02498

Reference yield:

2-Cyanopyridine (100-70-9,1232006-36-8) + isobutylmagnesium bromide → 3-methyl-1-(pyridin-2-yl) butan-1-one (6952-53-0)

Guidance literature:

2-Cyanopyridine; isobutylmagnesium bromide; In diethyl ether; at -15 - 20 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In diethyl ether; water; at 0 ℃; for 0.25h;

upstream raw materials:

2-Cyanopyridine

isobutylmagnesium bromide

2-bromo-pyridine

N-methoxy-N,3-dimethylbutanamide

Downstream raw materials:

2-hydroxy-4,5-bis(4-hydroxyphenyl)-2-isobutyl-1H-pyrrol-3(2H)-one

6-(2-methylpropyl)quinoline

4-isobutylquinoline

tert-butyl (3R,5S)-3-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-3-methyl-1-(2-pyridyl)butyl]carbamoyl}piperidine-1-carboxylate

Refernces

• 1、 Wu, Qingsong,Han, Shuaijun,Ren, Xiaoxiao,Lu, Hongtao,Li, Jingya,Zou, Dapeng,Wu, Yangjie,Wu, Yusheng. "Pd-Catalyzed Alkylation of (Iso)quinolines and Arenes: 2-Acylpyridine Compounds as Alkylation Reagents". supporting information. p. 6345 - 6348. Retrieved 2018/10/20.
• 2、 -. "NOVEL 2,4,6-TRI-SUBSTITUTED HETEROCYCLES AND USES THEREOF". Page 88. . Retrieved 2010/02/10.