4,5-diMethoxy-phthalic anhydride,

Base Information

• Chemical Name: 4,5-diMethoxy-phthalic anhydride,
• CAS No.: 4821-94-7
• Molecular Formula: C10H8O5
• Molecular Weight: 208.171
• Mol file: 4821-94-7.mol

Synonyms:1,3-Isobenzofurandione, 5,6-dimethoxy-;m-Hemipic anhydride;

Chemical Property of 4,5-diMethoxy-phthalic anhydride,

Chemical Property:

• Melting Point: 175 °C
• Boiling Point: 382.267 °C at 760 mmHg
• Flash Point: 174.104 °C
• PSA: 61.83000
• Density: 1.383 g/cm³
• LogP: 1.01440
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5,6-Dimethoxyisobenzofuran-1,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-diMethoxy-phthalic anhydride,

There total 1 articles about 4,5-diMethoxy-phthalic anhydride, which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

cyclotriveratrylene (1180-60-5) → 4,5-dimethoxyphthalic anhydride (4821-94-7) + C27H26O7

Guidance literature:

With manganese(IV) oxide; palladium diacetate; acetic acid; p-benzoquinone; for 12h; Reflux;

DOI:10.1039/c4ob02469a

Reference yield: 95.0%

4,5-dimethoxyphthalic anhydride (4821-94-7) + benzylamine (100-46-9) → 2-benzyl-5,6-dimethoxyisoindoline-1,3-dione (1054471-20-3)

Guidance literature:

With acetic acid; at 120 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.8b02287

Reference yield: 95.0%

4,5-dimethoxyphthalic anhydride (4821-94-7) + D-2-phenylglycinol (56613-80-0) → (R)-2-(2-hydroxy-1-phenylethyl)-5,6-dimethoxyisoindoline-1,3-dione

Guidance literature:

In neat (no solvent); at 160 - 170 ℃; for 7h;

DOI:10.1002/ejoc.202100368

upstream raw materials:

cyclotriveratrylene

Downstream raw materials:

2-(2,4-dimethoxy-benzyl)-4,5-dimethoxy-benzoic acid methyl ester

5,6-dimethoxy-3-((Ξ)-veratrylidene)-phthalide

4,5-dimethoxy-phthalic acid monoethyl ester

4,5-dimethoxy-2-benzoylbenzoic acid