1-((3,4-Dihydro-2H-1-benzopyran-3-yl)methyl)-4-(2-methoxyphenyl)piperazine dihydrochloride

Base Information

Chemical Name:1-((3,4-Dihydro-2H-1-benzopyran-3-yl)methyl)-4-(2-methoxyphenyl)piperazine dihydrochloride
CAS No.:83823-46-5
Molecular Formula:C₂₁H₂₆N₂O₂*2ClH
Molecular Weight:411.372
Hs Code.:
DSSTox Substance ID:DTXSID201003902

Synonyms:1-((3,4-Dihydro-2H-1-benzopyran-3-yl)methyl)-4-(2-methoxyphenyl)piperazine dihydrochloride;Piperazine, 1-((3,4-dihydro-2H-1-benzopyran-3-yl)methyl)-4-(2-methoxyphenyl)-, dihydrochloride;83823-46-5;DTXSID201003902;LS-111544;1-[(3,4-Dihydro-2H-1-benzopyran-3-yl)methyl]-4-(2-methoxyphenyl)piperazine--hydrogen chloride (1/2)

Suppliers and Price of 1-((3,4-Dihydro-2H-1-benzopyran-3-yl)methyl)-4-(2-methoxyphenyl)piperazine dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-((3,4-Dihydro-2H-1-benzopyran-3-yl)methyl)-4-(2-methoxyphenyl)piperazine dihydrochloride

Chemical Property:

Vapor Pressure:8.53E-10mmHg at 25°C
Boiling Point:491.2°C at 760 mmHg
Flash Point:142°C
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:410.1527835
Heavy Atom Count:27
Complexity:411

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1N2CCN(CC2)CC3CC4=CC=CC=C4OC3.Cl.Cl

Technology Process of 1-((3,4-Dihydro-2H-1-benzopyran-3-yl)methyl)-4-(2-methoxyphenyl)piperazine dihydrochloride

There total 7 articles about 1-((3,4-Dihydro-2H-1-benzopyran-3-yl)methyl)-4-(2-methoxyphenyl)piperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90-02-8
salicylaldehyde

: 83823-46-5
1-Chroman-3-ylmethyl-4-(2-methoxy-phenyl)-piperazine; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 16 percent / 20percent aq.NaOH

2: 94.7 percent / 10percent NaOH / 5 h / Heating

3: SOCl₂ / benzene / 3 h / Heating

4: Et₃N / benzene

5: LiAlH₄ / diethyl ether / Heating

6: 1) H₂ 2) HCl / 1) 10percent Pd/C / ethanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; benzene;

Reference yield:

: 83823-35-2
1-(2H-Chromen-3-ylmethyl)-4-(2-methoxy-phenyl)-piperazine

: 83823-46-5
1-Chroman-3-ylmethyl-4-(2-methoxy-phenyl)-piperazine; hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

Reference yield:

: 57543-66-5
2H-chromene-3-carbonitrile

: 83823-46-5
1-Chroman-3-ylmethyl-4-(2-methoxy-phenyl)-piperazine; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / 10percent NaOH / Heating

2: SOCl₂ / benzene / 3 h / Heating

3: Et₃N / benzene

4: LiAlH₄ / diethyl ether / Heating

5: 1) H₂ 2) HCl / 1) 10percent Pd/C / ethanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; benzene;