6,7-Dimethoxy-1-(4-nitrobenzyl)-3,4-dihydroisoquinoline

Base Information

Chemical Name:6,7-Dimethoxy-1-(4-nitrobenzyl)-3,4-dihydroisoquinoline
CAS No.:10268-39-0
Molecular Formula:C18H18 N2 O4
Molecular Weight:326.352
Hs Code.:
NSC Number:113109
DSSTox Substance ID:DTXSID60297015
Wikidata:Q82037918
Mol file:10268-39-0.mol

Synonyms:10268-39-0;6,7-dimethoxy-1-(4-nitrobenzyl)-3,4-dihydroisoquinoline;NSC113109;DTXSID60297015;NSC-113109

Suppliers and Price of 6,7-Dimethoxy-1-(4-nitrobenzyl)-3,4-dihydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 6,7-Dimethoxy-1-(4-nitrobenzyl)-3,4-dihydroisoquinoline

Chemical Property:

Vapor Pressure:7.91E-10mmHg at 25°C
Boiling Point:505.1°C at 760 mmHg
Flash Point:259.2°C
Density:1.26g/cm³
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:326.12665706
Heavy Atom Count:24
Complexity:468

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)CCN=C2CC3=CC=C(C=C3)[N+](=O)[O-])OC

Technology Process of 6,7-Dimethoxy-1-(4-nitrobenzyl)-3,4-dihydroisoquinoline

There total 7 articles about 6,7-Dimethoxy-1-(4-nitrobenzyl)-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 104-03-0
4-nitrobenzeneacetic acid

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 10268-39-0
6,7-dimethoxy-1-(4-nitro-benzyl)-3,4-dihydro-isoquinoline

Guidance literature:: With PPA; In dichloromethane; at 80 ℃; for 3h;
DOI:10.1016/0040-4020(96)00716-8

Reference yield:

: 10403-40-4
N-(3,4-dimethoxyphenethyl)-4-nitrophenylacetamide

: 10268-39-0
6,7-dimethoxy-1-(4-nitro-benzyl)-3,4-dihydro-isoquinoline

Guidance literature:: With trichlorophosphate; In acetonitrile; for 4h; Heating;
DOI:10.1021/jm960208o

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 10268-39-0
6,7-dimethoxy-1-(4-nitro-benzyl)-3,4-dihydro-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / toluene / 72 h / Heating

2: POCl₃ / acetonitrile / 4 h / Heating

With trichlorophosphate; In toluene; acetonitrile;
DOI:10.1021/jm960208o