2'-Adenylic acid, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-, 2-[[6-(benzoylamino)-9H-purin-9-yl]methoxy]ethyl 2-cyanoethyl ester

Base Information

Chemical Name:2'-Adenylic acid, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-, 2-[[6-(benzoylamino)-9H-purin-9-yl]methoxy]ethyl 2-cyanoethyl ester
CAS No.:486424-66-2
Molecular Formula:C56H52N11O11P
Molecular Weight:1086.07
Hs Code.:

2'-Adenylic acid,
N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-,
2-[[6-(benzoylamino)-9H-purin-9-yl]methoxy]ethyl 2-cyanoethyl ester

Synonyms:

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Chemical Property of 2'-Adenylic acid, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-, 2-[[6-(benzoylamino)-9H-purin-9-yl]methoxy]ethyl 2-cyanoethyl ester

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Technology Process of 2'-Adenylic acid, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-, 2-[[6-(benzoylamino)-9H-purin-9-yl]methoxy]ethyl 2-cyanoethyl ester

There total 5 articles about 2'-Adenylic acid, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-, 2-[[6-(benzoylamino)-9H-purin-9-yl]methoxy]ethyl 2-cyanoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 72710-11-3
N6-benzoyl-9-<(2-hydroxyethoxy)methyl>adenine

: 207347-42-0
N⁶-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 2'-(2-cyanoethyl diisopropylphosphoramidite)

: 486424-66-2
N⁶-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-adenylic acid 2-{[6-(benzoylamino)-9H-purin-9-yl]methoxy}ethyl 2-cyanoethyl ester

Guidance literature:: With 1H-tetrazole; In acetonitrile; for 3h;
DOI:10.1002/1522-2675(200208)85:8<2284::AID-HLCA2284>3.0.CO;2-E

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 486424-66-2
N⁶-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-adenylic acid 2-{[6-(benzoylamino)-9H-purin-9-yl]methoxy}ethyl 2-cyanoethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; Huenig's base / dioxane / 3 h / 20 °C

1.2: 69 percent / pyridine

2.1: 90 percent / 1H-tetrazole / acetonitrile / 2 h / 20 °C

3.1: 91 percent / 1H-tetrazole / acetonitrile / 3 h

With pyridine; 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile;
DOI:10.1002/1522-2675(200208)85:8<2284::AID-HLCA2284>3.0.CO;2-E

Reference yield:

: 73-03-0
cordycepin

: 486424-66-2
N⁶-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-adenylic acid 2-{[6-(benzoylamino)-9H-purin-9-yl]methoxy}ethyl 2-cyanoethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; Huenig's base / dioxane / 3 h / 20 °C

1.2: 69 percent / pyridine

2.1: 90 percent / 1H-tetrazole / acetonitrile / 2 h / 20 °C

3.1: 91 percent / 1H-tetrazole / acetonitrile / 3 h

With pyridine; 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile;
DOI:10.1002/1522-2675(200208)85:8<2284::AID-HLCA2284>3.0.CO;2-E