(R)-2-(9H-Fluorene-9-ylmethoxycarbonylamino)-3-(2-nitrophenylsulfonylamino)propionic acid

Base Information

Chemical Name:(R)-2-(9H-Fluorene-9-ylmethoxycarbonylamino)-3-(2-nitrophenylsulfonylamino)propionic acid
CAS No.:487027-90-7
Molecular Formula:C24H21N3O8S
Molecular Weight:511.512
Hs Code.:
DSSTox Substance ID:DTXSID901132207
Nikkaji Number:J1.843.574H
Mol file:487027-90-7.mol

Synonyms:487027-90-7;D-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-[[(2-nitrophenyl)sulfonyl]amino]-;Fmoc-D-Dap(Ns)-OH;DTXSID901132207;(R)-2-(9H-Fluorene-9-ylmethoxycarbonylamino)-3-(2-nitrophenylsulfonylamino)propionic acid;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[[(2-nitrophenyl)sulfonyl]amino]-D-alanine

Suppliers and Price of (R)-2-(9H-Fluorene-9-ylmethoxycarbonylamino)-3-(2-nitrophenylsulfonylamino)propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(9H-Fluorene-9-ylmethoxycarbonylamino)-3-(2-nitrophenylsulfonylamino)propionic acid

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:9
Exact Mass:511.10493581
Heavy Atom Count:36
Complexity:895

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CNS(=O)(=O)C4=CC=CC=C4[N+](=O)[O-])C(=O)O
Isomeric SMILES:C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@H](CNS(=O)(=O)C4=CC=CC=C4[N+](=O)[O-])C(=O)O

Technology Process of (R)-2-(9H-Fluorene-9-ylmethoxycarbonylamino)-3-(2-nitrophenylsulfonylamino)propionic acid

There total 5 articles about (R)-2-(9H-Fluorene-9-ylmethoxycarbonylamino)-3-(2-nitrophenylsulfonylamino)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₉N₃O₈SSi

: 487027-90-7
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-nitro-benzenesulfonylamino)-propionic acid

Guidance literature:: With methanol; at 20 ℃; for 1h;
DOI:10.1021/jo020447l

Reference yield:

: Fmoc-D-Asn-OH

: 487027-90-7
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-nitro-benzenesulfonylamino)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis(trifluoroacetoxy)iodobenzene; pyridine / dimethylformamide; H₂O / 24 h / 20 °C

1.2: 89 percent / aq. HCl

2.1: Et₃N / CH₂Cl₂ / Heating

3.1: Et₃N / CH₂Cl₂ / 4 h / 20 °C

4.1: 7.01 g / MeOH / 1 h / 20 °C

With pyridine; methanol; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo020447l

Reference yield:

: C₂₁H₂₆N₂O₄Si

: 487027-90-7
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-nitro-benzenesulfonylamino)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 4 h / 20 °C

2: 7.01 g / MeOH / 1 h / 20 °C

With methanol; triethylamine; In dichloromethane;
DOI:10.1021/jo020447l