Naphthalene, 1,8-bis(4-methoxy-3-methylphenyl)-2,7-bis(1-methylethoxy)-

Base Information

• Chemical Name: Naphthalene, 1,8-bis(4-methoxy-3-methylphenyl)-2,7-bis(1-methylethoxy)-
• CAS No.: 487945-04-0
• Molecular Formula: C₃₂H₃₆O₄
• Molecular Weight: 484.635
• Mol file: 487945-04-0.mol

Synonyms:

Chemical Property of Naphthalene, 1,8-bis(4-methoxy-3-methylphenyl)-2,7-bis(1-methylethoxy)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Naphthalene, 1,8-bis(4-methoxy-3-methylphenyl)-2,7-bis(1-methylethoxy)-

There total 3 articles about Naphthalene, 1,8-bis(4-methoxy-3-methylphenyl)-2,7-bis(1-methylethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

4-methoxy-3-methylphenylboronic acid (175883-62-2) + 1,8-dibromo-2,7-diisopropyxynaphthalene (487944-81-0) → 2,7-diisopropoxy-1-(4-methoxy-3-methylphenyl)naphthalene + 1-bromo-2,7-diisopropoxy-8-(4-methoxy-3-methylphenyl)naphthalene + 2,7-diisopropoxy-1,8-bis(4-methoxy-3-methylphenyl)naphthalene (487945-04-0)

Guidance literature:

With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl acetamide; water; at 70 - 80 ℃; for 72h;

DOI:10.1039/b201235a

Reference yield:

2,7-Dihydroxynaphthalene (582-17-2) → 2,7-diisopropoxy-1,8-bis(4-methoxy-3-methylphenyl)naphthalene (487945-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate; tetrabutylammonium iodide / dimethylformamide

1.2: 61 percent / dimethylformamide / 9 h / 70 °C

2.1: 40 percent / NBS; pyridine / CHCl₃ / 9 h / Heating

3.1: Ba(OH)2*10H₂O; Pd(PPh₃)4 / N,N-dimethyl-acetamide; H₂O / 72 h / 70 - 80 °C

With pyridine; barium dihydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetra-(n-butyl)ammonium iodide; potassium carbonate; In chloroform; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 3.1: Suzuki coupling;

DOI:10.1039/b201235a

Reference yield:

2,7-diisopropoxynaphthalene (487944-70-7) → 2,7-diisopropoxy-1,8-bis(4-methoxy-3-methylphenyl)naphthalene (487945-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / NBS; pyridine / CHCl₃ / 9 h / Heating

2: Ba(OH)2*10H₂O; Pd(PPh₃)4 / N,N-dimethyl-acetamide; H₂O / 72 h / 70 - 80 °C

With pyridine; barium dihydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In chloroform; N,N-dimethyl acetamide; water; 2: Suzuki coupling;

DOI:10.1039/b201235a

upstream raw materials:

4-methoxy-3-methylphenylboronic acid

1,8-dibromo-2,7-diisopropyxynaphthalene

2,7-Dihydroxynaphthalene

2,7-diisopropoxynaphthalene