Pentanal, 3-[(3,4-dimethoxyphenyl)methoxy]-2-methyl-, (2R,3R)-

Base Information

Chemical Name:Pentanal, 3-[(3,4-dimethoxyphenyl)methoxy]-2-methyl-, (2R,3R)-
CAS No.:488099-61-2
Molecular Formula:C15H22O4
Molecular Weight:266.337
Hs Code.:

Synonyms:

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Chemical Property of Pentanal, 3-[(3,4-dimethoxyphenyl)methoxy]-2-methyl-, (2R,3R)-

Chemical Property:

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Technology Process of Pentanal, 3-[(3,4-dimethoxyphenyl)methoxy]-2-methyl-, (2R,3R)-

There total 6 articles about Pentanal, 3-[(3,4-dimethoxyphenyl)methoxy]-2-methyl-, (2R,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96016-23-8
(2S,3R)-3-(3,4-Dimethoxy-benzyloxy)-2-methyl-pentan-1-ol

: 488099-61-2
(2R,3R)-3-(3,4-Dimethoxy-benzyloxy)-2-methyl-pentanal

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃;
DOI:10.1021/ol0272343

Reference yield:

: 30414-53-0
methyl propanoyl acetate

: 488099-61-2
(2R,3R)-3-(3,4-Dimethoxy-benzyloxy)-2-methyl-pentanal

Guidance literature:: Multi-step reaction with 6 steps

1.1: 99 percent / H₂; Amberlyst 15 / (R)-Binap-Ru(II)Cl₂ / methanol / 100 °C / 3102.97 Torr

2.1: LDA / tetrahydrofuran / -78 °C

2.2: HMPA

3.1: LAH / diethyl ether / 0 °C

4.1: TsOH / benzene / Heating

5.1: DIBAL-H / CH₂Cl₂ / -78 °C

6.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

With lithium aluminium tetrahydride; Amberlyst 15; oxalyl dichloride; hydrogen; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; RuCl₂[(R)-BINAP]; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene; 2.2: Frater-Seebach alkylation / 6.1: Swern oxidation;
DOI:10.1021/ol0272343

Reference yield:

: 78655-79-5
2(R),3(R) methyl 3-hydroxy-2-methylpentanoate

: 488099-61-2
(2R,3R)-3-(3,4-Dimethoxy-benzyloxy)-2-methyl-pentanal

Guidance literature:: Multi-step reaction with 4 steps

1: LAH / diethyl ether / 0 °C

2: TsOH / benzene / Heating

3: DIBAL-H / CH₂Cl₂ / -78 °C

4: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

With lithium aluminium tetrahydride; oxalyl dichloride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In diethyl ether; dichloromethane; benzene; 4: Swern oxidation;
DOI:10.1021/ol0272343