Technology Process of 3-Oxoninol,
9-ethyl-2,3,4,9-tetrahydro-2-[2-[(4-methoxyphenyl)methoxy]ethyl]-,
(2S,3R,5Z,7Z,9S)-
There total 14 articles about 3-Oxoninol,
9-ethyl-2,3,4,9-tetrahydro-2-[2-[(4-methoxyphenyl)methoxy]ethyl]-,
(2S,3R,5Z,7Z,9S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
[(ν3-allyl)PdCl]2; tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 61h;
DOI:10.1021/ja0466863
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 95 percent / N-iodosuccinimide; AgNO3 / dimethylformamide / 0.17 h / 20 °C
2.1: 80 percent / potassium azodicarboxylate; AcOH / tetrahydrofuran; propan-2-ol / 6 h / 20 °C
3.1: AlEt3 / CH2Cl2; toluene / 1 h / 0 - 20 °C
3.2: 93 percent / CH2Cl2; toluene / 0 - 20 °C
4.1: 82 percent / Ag2O / CH2Cl2 / 24 h / 20 °C
5.1: 87 percent / DIBAL-H / CH2Cl2; hexane / 3 h / -73 °C
6.1: 4.10 g / diethyl ether / 2 h / -100 - -95 °C
7.1: 91 percent / Et3N / CH2Cl2 / 0 - 20 °C
8.1: 92 percent / [(CF3)2MeCO]2Mo(=CHCMe2Ph)(=NC6H3-2,6-i-Pr2) / benzene / 1 h / 20 °C
9.1: 61 percent / [(π-allyl)PdCl]2; TBAF*3H2O / tetrahydrofuran / 61 h / 20 °C
With
N-iodo-succinimide; bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum; [(ν3-allyl)PdCl]2; tetrabutyl ammonium fluoride; triethylaluminum; potassium diazodicarboxylate; diisobutylaluminium hydride; silver nitrate; acetic acid; triethylamine; silver(l) oxide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; benzene;
DOI:10.1021/ja0466863
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: AlEt3 / CH2Cl2; toluene / 1 h / 0 - 20 °C
1.2: 93 percent / CH2Cl2; toluene / 0 - 20 °C
2.1: 82 percent / Ag2O / CH2Cl2 / 24 h / 20 °C
3.1: 87 percent / DIBAL-H / CH2Cl2; hexane / 3 h / -73 °C
4.1: 4.10 g / diethyl ether / 2 h / -100 - -95 °C
5.1: 91 percent / Et3N / CH2Cl2 / 0 - 20 °C
6.1: 92 percent / [(CF3)2MeCO]2Mo(=CHCMe2Ph)(=NC6H3-2,6-i-Pr2) / benzene / 1 h / 20 °C
7.1: 61 percent / [(π-allyl)PdCl]2; TBAF*3H2O / tetrahydrofuran / 61 h / 20 °C
With
bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum; [(ν3-allyl)PdCl]2; tetrabutyl ammonium fluoride; triethylaluminum; diisobutylaluminium hydride; triethylamine; silver(l) oxide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; benzene;
DOI:10.1021/ja0466863
![(6R)-2,2-dimethyl-6-{(1S)-1-{[(1S,2Z)-1-ethyl-3-iodo-2-propenyl]oxy}-3-(4-methoxybenzyloxy)propan-1-yl}-1-oxa-2-silacyclohex-3-ene](/Databaselist/images/loading.webp)
