Technology Process of Carbamic acid, [(3S,4S)-4-ethyl-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI)
There total 17 articles about Carbamic acid, [(3S,4S)-4-ethyl-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 84 percent / diethyl ether / 0.25 h / 0 °C
2: 86 percent / MsCl; Et3N / CH2Cl2 / 1 h / -15 - 20 °C
3: 91 percent / p-TsOH / methanol / 20 h / 55 °C
4: 66 percent / Ph3P; DEAD / benzene / 1 h
5: 86 percent / Cl2Ru(=CHPh)[(P(c-Hex)3]2 / CH2Cl2 / 12 h / Heating
6: H2 / Pd/C / methanol
7: i-PrNH2 / CH2Cl2 / 0.17 h / 20 °C
With
Grubbs catalyst first generation; hydrogen; toluene-4-sulfonic acid; methanesulfonyl chloride; isopropylamine; triethylamine; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
methanol; diethyl ether; dichloromethane; benzene;
5: modified Mitsunobu reaction;
DOI:10.1021/jm030272n
- Guidance literature:
-
With
isopropylamine;
In
dichloromethane;
at 20 ℃;
for 0.166667h;
DOI:10.1021/jm030272n
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 66 percent / Ph3P; DEAD / benzene / 1 h
2: 86 percent / Cl2Ru(=CHPh)[(P(c-Hex)3]2 / CH2Cl2 / 12 h / Heating
3: H2 / Pd/C / methanol
4: i-PrNH2 / CH2Cl2 / 0.17 h / 20 °C
With
Grubbs catalyst first generation; hydrogen; isopropylamine; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
methanol; dichloromethane; benzene;
2: modified Mitsunobu reaction;
DOI:10.1021/jm030272n