Benzenemethanol, alpha-(1-((2,3-dihydro-2-methyl-1,4-benzodioxin-2-yl)methyl)amino)ethyl)-4-hydroxy-, hydrobromide

Base Information

Chemical Name:Benzenemethanol, alpha-(1-((2,3-dihydro-2-methyl-1,4-benzodioxin-2-yl)methyl)amino)ethyl)-4-hydroxy-, hydrobromide
CAS No.:87081-19-4
Molecular Formula:BrH*C₁₉H₂₃NO₄
Molecular Weight:410.308
Hs Code.:
DSSTox Substance ID:DTXSID401007324

Synonyms:87081-19-4;Benzenemethanol, alpha-(1-((2,3-dihydro-2-methyl-1,4-benzodioxin-2-yl)methyl)amino)ethyl)-4-hydroxy-, hydrobromide;C19H23NO4.BrH;C19-H23-N-O4.Br-H;DTXSID401007324;LS-30688;4-(1-Hydroxy-2-{[(2-methyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amino}propyl)phenol--hydrogen bromide (1/1)

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzenemethanol, alpha-(1-((2,3-dihydro-2-methyl-1,4-benzodioxin-2-yl)methyl)amino)ethyl)-4-hydroxy-, hydrobromide

Chemical Property:

Vapor Pressure:1.26E-11mmHg at 25°C
Boiling Point:519.7°C at 760 mmHg
Flash Point:268.1°C
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:409.08887
Heavy Atom Count:25
Complexity:399

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(C1=CC=C(C=C1)O)O)NCC2(COC3=CC=CC=C3O2)C.Br

Technology Process of Benzenemethanol, alpha-(1-((2,3-dihydro-2-methyl-1,4-benzodioxin-2-yl)methyl)amino)ethyl)-4-hydroxy-, hydrobromide

There total 4 articles about Benzenemethanol, alpha-(1-((2,3-dihydro-2-methyl-1,4-benzodioxin-2-yl)methyl)amino)ethyl)-4-hydroxy-, hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 2-[Benzyl-(2-methyl-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-amino]-1-(4-benzyloxy-phenyl)-propan-1-one; hydrobromide

: 87081-19-4
4-{1-Hydroxy-2-[(2-methyl-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-amino]-propyl}-phenol; hydrobromide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; water; at 60 ℃; under 2280 Torr;

Reference yield:

: 16163-78-3
2,3-dihydro-2-methyl-1,4-benzodioxin-2-methyl 4-tolylsulfonate

: 87081-19-4
4-{1-Hydroxy-2-[(2-methyl-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-amino]-propyl}-phenol; hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / dimethylsulfoxide / 24 h / 120 °C

2: 19 percent / 1) Et₃N, 2) HCl / ethanol / 20 h / Heating

3: 13 percent / H₂ / 5percent Pd/C / ethanol; H₂O / 60 °C / 2280 Torr

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; water; dimethyl sulfoxide;

Reference yield:

: 35081-45-9
1-<4-(benzyloxy)phenyl>-2-bromo-1-propanone

: 87081-19-4
4-{1-Hydroxy-2-[(2-methyl-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-amino]-propyl}-phenol; hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: 19 percent / 1) Et₃N, 2) HCl / ethanol / 20 h / Heating

2: 13 percent / H₂ / 5percent Pd/C / ethanol; H₂O / 60 °C / 2280 Torr

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; water;